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公开(公告)号：US20240132843A1
公开(公告)日：2024-04-25
申请号：US18547627
申请日：2022-02-23
发明人： John CHO , Kerem Jonatan TUNCEL
IPC分类号： C12N5/0783 , A61K39/00 , C12N9/22 , C12N15/11 , C12N15/90
CPC分类号： C12N5/0637 , A61K39/4611 , C12N9/22 , C12N15/11 , C12N15/907 , A61K2239/26 , C12N2501/2302 , C12N2501/51 , C12N2501/515 , C12N2501/53
摘要： Provided herein are ex vivo methods for expanding regulatory T cells (Tregs), including engineered Tregs, while maintaining their stability and activity. In addition to improving growth and expansion of Tregs, the methods, which can comprise the use of discontinuous stimulation of regulatory T cells (DSORT™), produce Tregs with increased stability and activity.
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公开(公告)号：US20220110974A1
公开(公告)日：2022-04-14
申请号：US17426059
申请日：2020-01-31
发明人： John CHO , Jason MERKIN , Noah Jacob TUBO , James Martin KABERNA, II , Solomon Martin SHENKER , Kerem Jonatan TUNCEL
IPC分类号： A61K35/17 , C12N15/113 , C12N9/22 , C07K14/705 , C07K14/47 , A61P37/00
摘要： The present disclosure provides methods and compositions related to the modification of Tregs to increase therapeutic efficacy. In some embodiments, Tregs modified to reduce expression of one or more endogenous target genes, or to reduce one or more functions of an endogenous protein to enhance immunosuppressive functions of the immune cells are provided. In some embodiments, Tregs further modified by introduction of transgenes conferring antigen specificity, such as exogenous T cell receptors (TCRs) or chimeric antigen receptors (CARs) are provided. Methods of treating an autoimmune diseases using the modified Tregs described herein are also provided.
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公开(公告)号：US20240182594A1
公开(公告)日：2024-06-06
申请号：US18551375
申请日：2022-03-18
CPC分类号： C07K16/2878 , G01N33/5023 , G01N33/505 , C07K2317/21 , C07K2317/24 , C07K2317/76 , G01N2500/10
摘要： The present disclosure provides methods of increasing the activity of regulatory T cells (Tregs), e.g., to treat autoimmune or inflammatory diseases or disorders, using antagonist, nondepleting antibodies and antigen-binding fragments thereof that specifically bind to OX40 (e.g., human OX40).
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公开(公告)号：US20240228962A9
公开(公告)日：2024-07-11
申请号：US18547627
申请日：2022-02-23
发明人： John CHO , Kerem Jonatan TUNCEL
IPC分类号： C12N5/0783 , A61K39/00 , C12N9/22 , C12N15/11 , C12N15/90
CPC分类号： C12N5/0637 , A61K39/4611 , C12N9/22 , C12N15/11 , C12N15/907 , A61K2239/26 , C12N2501/2302 , C12N2501/51 , C12N2501/515 , C12N2501/53
摘要： Provided herein are ex vivo methods for expanding regulatory T cells (Tregs), including engineered Tregs, while maintaining their stability and activity. In addition to improving growth and expansion of Tregs, the methods, which can comprise the use of discontinuous stimulation of regulatory T cells (DSORT™), produce Tregs with increased stability and activity.
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