公开(公告)号：US11629189B2

公开(公告)日：2023-04-18

申请号：US16955219

申请日：2018-12-19

申请人： KYMAB LIMITED

发明人： Matthew John McCourt ,  Richard Charles Alfred Sainson ,  Jamie Iain Campbell ,  Stephen John Arkinstall ,  Mihriban Tuna ,  Ryan Fiehler ,  Mustapha Faroudi ,  Fadi Badr ,  Francisca Wollerton Van Horck ,  Frederick Akele

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/00

摘要： Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and CTLA-4, in addition to anti-ICOS and anti-PD-L1.