公开(公告)号：US11440960B2

公开(公告)日：2022-09-13

申请号：US16623929

申请日：2018-06-20

申请人： Kymab Limited

发明人： Joana de Abreu Carvalho ,  Rachael Jane Kimber ,  Jamie Ian Campbell ,  Nikole Sandy ,  Cassandra Van Krinks ,  Stephen John Arkinstall ,  Volker Germaschewski ,  Ian Kirby ,  Miha Kosmac ,  Thomas Gallagher ,  Matthew John McCourt ,  Richard Charles Alfred Sainson ,  Mohammed Hanif Ali ,  E-Chiang Lee ,  Stephen Douglas Gillies

IPC分类号： A61P35/00 ,  A61K39/395 ,  A61K39/00 ,  C07K16/28

摘要： The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

公开(公告)号：US09957323B2

公开(公告)日：2018-05-01

申请号：US15698600

申请日：2017-09-07

申请人： KYMAB LIMITED

发明人： Richard Charles Alfred Sainson ,  Stephen John Arkinstall ,  Jamie Iain Campbell ,  Mohammed Hanif Ali ,  E-Chiang Lee ,  Matthew John McCourt ,  Nikole Sandy ,  Cassandra Van Krinks ,  Volker Germaschewski ,  Ian Kirby ,  Miha Kosmac ,  Thomas Gallagher ,  Cecilia Deantonio ,  Stephen D. Gillies

IPC分类号： C07K16/28 ,  A61K39/395 ,  C07K16/46 ,  C07K14/55

CPC分类号： C07K16/2827 ,  A61K2039/505 ,  C07K14/55 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/468 ,  C07K19/00 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/524 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/74

摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

公开(公告)号：US11858996B2

公开(公告)日：2024-01-02

申请号：US16323980

申请日：2017-08-09

申请人： Kymab Limited

发明人： Richard Charles Alfred Sainson ,  Stephen John Arkinstall ,  Jamie Iain Campbell ,  Mohammed Hanif Ali ,  E-Chiang Lee ,  Matthew John McCourt ,  Volker Germaschewski ,  Ian Kirby ,  Miha Kosmac ,  Nahida Parveen ,  Robert Rowlands ,  Gwenoline Borhis

IPC分类号： C07K16/02 ,  A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  A61K47/68 ,  A61K31/282 ,  C07K14/55 ,  C07K16/46 ,  G01N33/50 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K31/282 ,  A61K39/395 ,  A61K47/6849 ,  A61P35/00 ,  C07K14/55 ,  C07K16/2827 ,  C07K16/468 ,  G01N33/5026 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

公开(公告)号：US11629189B2

公开(公告)日：2023-04-18

申请号：US16955219

申请日：2018-12-19

申请人： KYMAB LIMITED

发明人： Matthew John McCourt ,  Richard Charles Alfred Sainson ,  Jamie Iain Campbell ,  Stephen John Arkinstall ,  Mihriban Tuna ,  Ryan Fiehler ,  Mustapha Faroudi ,  Fadi Badr ,  Francisca Wollerton Van Horck ,  Frederick Akele

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/00

摘要： Multispecific antibody in mAb2 format, comprising an ICOS-binding Fab region and a PD-L1-binding Fcab region. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours. Combination therapy including antibody to another immune checkpoint molecule such as PD-1 and CTLA-4, in addition to anti-ICOS and anti-PD-L1.