公开(公告)号：US20190330596A1

公开(公告)日：2019-10-31

申请号：US16312789

申请日：2017-06-21

Applicant: KYOTO UNIVERSITY

Inventor： Shin KANEKO ,  Yutaka YASUI ,  Shoichi IRIGUCHI ,  Tatsuki UEDA

IPC: C12N5/074 ,  C12N5/10 ,  C12N15/85 ,  C12N5/0783 ,  C07K14/725 ,  C07D401/04

Abstract: A method for producing CD4/CD8 double-positive T cells, comprising the steps of: (1) culturing pluripotent stem cells in a medium to induce hematopoietic progenitor cells; and (2) culturing the hematopoietic progenitor cells obtained in the step (1) in a medium containing a p38 inhibitor and/or SDF-1 to induce CD4/CD8 double-positive T cells.

公开(公告)号：US20230257705A1

公开(公告)日：2023-08-17

申请号：US18002009

申请日：2021-06-16

Applicant: KYOTO UNIVERSITY

Inventor： Shin KANEKO ,  Tatsuki UEDA

IPC: C12N5/0783 ,  C07K14/54 ,  A61K35/17 ,  A61P35/00

CPC classification number: C12N5/0636 ,  C07K14/5443 ,  A61K35/17 ,  A61P35/00 ,  C07K2319/03 ,  C07K2319/32 ,  C07K2319/74

Abstract: The present invention aims to increase cytotoxic activity of an immunocompetent cell to thereby enhance a therapeutic effect against diseases such as cancers, and provides an immunocompetent cell having decreased diacylglycerol kinase activity, which cell expresses a fusion protein including IL-15 and an IL-15 receptor α subunit, and which cell expresses a chimeric antigen receptor.