公开(公告)号：US20160067206A1

公开(公告)日：2016-03-10

申请号：US14767767

申请日：2013-02-20

申请人： KYUNGPOOK NATIONAL UNIVERITY INDUSTRY- ACADEMIC COOPERATION FOUNDATION ,  KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL

发明人： In Kyu Lee ,  Keun Gyu Park ,  Chang Joo Oh

IPC分类号： A61K31/225 ,  A23L1/30 ,  A61K9/00

CPC分类号： A61K31/225 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/146 ,  A61K9/2059

摘要： The present invention relates to a composition for preventing or treating renal fibrosis comprising dimethylfumarate (DMF) as an active ingredient. The DMF according to the present invention has an excellent effect of reducing renal fibrosis by activating Nrf2 to inhibit TGF-β/Smad signaling, and thus is useful for preventing or treating renal fibrosis.

摘要翻译： 本发明涉及包含富马酸二甲酯（DMF）作为活性成分的用于预防或治疗肾纤维化的组合物。 根据本发明的DMF具有通过激活Nrf2以抑制TGF-β/ Smad信号传导来减少肾纤维化的优异效果，因此可用于预防或治疗肾纤维化。

公开(公告)号：US09724320B2

公开(公告)日：2017-08-08

申请号：US14767767

申请日：2013-02-20

申请人： KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION ,  KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL

发明人： In Kyu Lee ,  Keun Gyu Park ,  Chang Joo Oh ,  Han Jong Kim ,  Joon-Young Kim

IPC分类号： A61K31/225 ,  A61K9/00 ,  A61K9/14 ,  A61K9/20 ,  A23L33/10

CPC分类号： A61K31/225 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/146 ,  A61K9/2059

摘要： The present invention relates to a composition for preventing or treating renal fibrosis comprising dimethylfumarate (DMF) as an active ingredient. The DMF according to the present invention has an excellent effect of reducing renal fibrosis by activating Nrf2 to inhibit TGF-β/Smad signaling, and thus is useful for preventing or treating renal fibrosis.