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公开(公告)号：US20190060314A1
公开(公告)日：2019-02-28
申请号：US15737916
申请日：2016-06-24
IPC分类号： A61K31/519 , A61P33/06 , A61K31/52
CPC分类号： A61K31/519 , A61K31/52 , A61K31/5377 , A61P33/06 , C07D231/16 , C07D239/70 , C07D471/04 , C07D473/34 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04 , C07D513/04 , Y02A50/409 , Y02A50/411
摘要： Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.
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公开(公告)号：US20190315772A1
公开(公告)日：2019-10-17
申请号：US16397043
申请日：2019-04-29
发明人： Kellen L. Olszewski , Ji-In Kim , Masha V. Poyurovsky , Kevin G. Liu , Anthony Barsotti , Koi Morris
IPC分类号： C07D513/04 , A61P35/04 , C07D495/04 , C07D491/048 , C07D487/04 , A61K45/06 , C07D471/04 , A61K31/5377 , A61K31/52 , A61K31/519 , C07D473/34
摘要： Provided hererin are compounds that modulate glucose uptake activityand are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and the known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: wherein the variables have the values disclosed herein.
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公开(公告)号：US10729691B2
公开(公告)日：2020-08-04
申请号：US15737916
申请日：2016-06-24
IPC分类号： A61K31/519 , A61K31/52 , C07D239/70 , C07D231/16 , A61K31/5377 , C07D513/04 , C07D471/04 , C07D491/048 , C07D473/34 , C07D495/04 , C07D487/04 , C07D491/052 , A61P33/06
摘要： Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.
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公开(公告)号：US20180298029A1
公开(公告)日：2018-10-18
申请号：US15737911
申请日：2016-06-24
发明人： Kellen Olszewski , Ji-Ln Kim , Masha Poyurovsky , Kevin G. Liu , Anthony Barsotti , Koi Morris
IPC分类号： C07D513/04 , C07D495/04 , C07D491/048 , C07D487/04 , C07D473/34 , C07D471/04 , A61P35/04
CPC分类号： C07D513/04 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K45/06 , A61P35/04 , C07D471/04 , C07D473/34 , C07D487/04 , C07D491/048 , C07D495/04 , A61K2300/00
摘要： Provided herein are compounds that modulate glucose uptake activity and are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: Formula (I) wherein the variables have the values disclosed herein.
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公开(公告)号：US10988484B2
公开(公告)日：2021-04-27
申请号：US16397043
申请日：2019-04-29
发明人： Kellen L. Olszewski , Ji-In Kim , Masha V. Poyurovsky , Kevin G. Liu , Anthony Barsotti , Koi Morris
IPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , C07D487/04 , C07D513/04 , A61K45/06 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D473/34 , C07D491/048 , A61P35/04
摘要： Provided herein are compounds that modulate glucose uptake activity and are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and the known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: wherein the variables have the values disclosed herein.
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公开(公告)号：US10273248B2
公开(公告)日：2019-04-30
申请号：US15737911
申请日：2016-06-24
发明人： Kellen L. Olszewski , Ji-In Kim , Masha V. Poyurovsky , Kevin G. Liu , Anthony Barsotti , Koi Morris
IPC分类号： C07D471/04 , C07D491/048 , C07D487/04 , C07D495/04 , C07D513/04 , A61K45/06 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D473/34 , A61P35/04
摘要： Provided herein are compounds that modulate glucose uptake activity and are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: Formula (I) wherein the variables have the values disclosed herein.
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