公开(公告)号：US20230063066A1

公开(公告)日：2023-03-02

申请号：US16959653

申请日：2018-12-21

申请人： Kai WANG ,  Yong ZHOU ,  Shizhen QIN ,  Xiaogang WU ,  Institute for Systems Biology

发明人： Kai WANG ,  Yong ZHOU ,  Shizhen QIN ,  Xiaogang WU

IPC分类号： C12Q1/6883 ,  G01N33/569

摘要： Reagents and methods to use said reagents for detection of markers of various aspects of Lyme disease have been identified in biological fluids thus permitting diagnosis or classification of Lyme disease subjects as well as indicating suitable methods of treatment.

公开(公告)号：US20130225428A1

公开(公告)日：2013-08-29

申请号：US13691170

申请日：2012-11-30

申请人： Institute For Systems Biology

发明人： Shizhen QIN ,  Leroy Hood

IPC分类号： C12Q1/68 ,  G01N33/68

CPC分类号： C12Q1/6876 ,  G01N33/6893

摘要： New markers for diseased liver conditions have been identified. A combination of protein C (PROC) and retinol binding protein 4 (RBP4) in blood are biomarkers to distinguish patients at different stages of hepatic fibrosis due, for example, to chronic infection with hepatitis C virus (HCV). Also, alpha-1-B glycoprotein (A1BG), complement factor H (CFH) and insulin-like growth factor binding protein acid labile subunit (IGFALS) distinguish subjects with chronic or acute liver conditions such as hepatitis infection or liver fibrosis from healthy controls.

摘要翻译： 已经确定了患病肝脏疾病的新标志物。 血液中蛋白C（PROC）和视黄醇结合蛋白4（RBP4）的组合是生物标志物，以区分肝纤维化的不同阶段的患者，例如由于丙型肝炎病毒（HCV）的慢性感染。 此外，α-1-B糖蛋白（A1BG），补体因子H（CFH）和胰岛素样生长因子结合蛋白酸不稳定亚基（IGFALS）区分来自健康对照的慢性或急性肝病例如肝炎感染或肝纤维化的受试者 。