公开(公告)号：US20180252730A1

公开(公告)日：2018-09-06

申请号：US15580855

申请日：2016-06-10

申请人： Kanazawa University ,  Shiseido Company. Ltd

发明人： Takashi Wada ,  Kengo FURUICHI ,  Norihiro SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Yurika MIYOSHI ,  Maiko NAKANE ,  Masashi MITA

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6806 ,  G01N2800/347

摘要： The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.

公开(公告)号：US20210283082A1

公开(公告)日：2021-09-16

申请号：US16972906

申请日：2019-06-06

申请人： National University Corporation Kanazawa University ,  Kagami Inc.

发明人： Takashi WADA ,  Kengo FURUICHI ,  Norihiko SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Masashi MITA

IPC分类号： A61K31/198 ,  A61P13/12 ,  A61K9/00

摘要： The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, an inflammation inhibitor for the kidneys, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-serine or a derivative thereof. In addition, the present invention pertains to the use of D-serine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.

公开(公告)号：US20210220309A1

公开(公告)日：2021-07-22

申请号：US16972898

申请日：2019-06-06

申请人： National University Corporation Kanazawa University ,  Kagami Inc.

发明人： Takashi WADA ,  Kengo FURUICHI ,  Norihiko SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Masashi MITA

IPC分类号： A61K31/198 ,  A61P13/12 ,  A61K9/00

摘要： The present invention pertains to a pharmaceutical composition for the prevention or treatment of kidney disease, a kidney inflammation inhibitor, an inflammatory cell death inhibitor for the kidneys, or a food for the prevention or improvement of kidney disease, that include D-alanine or a derivative thereof. In addition, the present invention pertains to the use of D-alanine or a derivative thereof, for the production of a pharmaceutical composition for the prevention or treatment of kidney disease.