公开(公告)号：US20180252730A1

公开(公告)日：2018-09-06

申请号：US15580855

申请日：2016-06-10

申请人： Kanazawa University ,  Shiseido Company. Ltd

发明人： Takashi Wada ,  Kengo FURUICHI ,  Norihiro SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Yurika MIYOSHI ,  Maiko NAKANE ,  Masashi MITA

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/6806 ,  G01N2800/347

摘要： The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.

公开(公告)号：US09952235B2

公开(公告)日：2018-04-24

申请号：US15450135

申请日：2017-03-06

申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD. ,  AJINOMOTO CO., INC.

发明人： Masako Hayakawa ,  Kazutaka Shimbo ,  Hiroo Yoshida

IPC分类号： G01N33/96 ,  G01N33/68 ,  G01N30/04

CPC分类号： G01N33/96 ,  G01N33/6806 ,  G01N33/6848 ,  G01N2030/042 ,  G01N2496/80 ,  Y10T436/105831 ,  Y10T436/106664

摘要： An external standard solution for use in the analysis of amino acid in plasma, containing, (1) at least one amino acid selected from the following components A, at a concentration of 0.0007 M to 0.49 M, and (2) (i) at least one amino acid selected from the following components B, at a concentration of 0.2 to 0.9 times of the lowest-concentration amino acid among the amino acids selected from components A, (ii) at least one amino acid selected from the following components C, at a concentration of 0.1 to 0.4 times of the lowest-concentration amino acid among amino acids selected from the components A, or (iii) at least one amino acid selected from the following components D, at a concentration of 0.05 to 0.2 times of the lowest-concentration amino acid among amino acids selected from the components A; [Components A] valine, glycine, alanine and glutamine [Components B] serine, proline, threonine, taurine, leucine, isoleucine, lysine, histidine, phenylalanine and tyrosine [Components C] asparagine, ornithine, arginine and tryptophan [Components D] glutamic acid, methionine, citrulline and cystine.

公开(公告)号：US20180094013A1

公开(公告)日：2018-04-05

申请号：US15832028

申请日：2017-12-05

申请人： Phytoquest Limited

发明人： Robert James Nash

IPC分类号： C07H7/02 ,  H01J49/00 ,  G01N33/68 ,  G01N30/72 ,  G01N30/06 ,  A61K36/81 ,  A61K36/38 ,  A61K36/28 ,  A61K36/23 ,  A61K36/19 ,  A61K36/87 ,  A61K36/66

CPC分类号： C07H7/02 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/38 ,  A61K36/66 ,  A61K36/81 ,  A61K36/87 ,  G01N30/06 ,  G01N30/7206 ,  G01N33/6806 ,  H01J49/0027

摘要： Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).

公开(公告)号：US09862921B2

公开(公告)日：2018-01-09

申请号：US14896123

申请日：2014-06-17

申请人： Hitachi High-Technologies Corporation

发明人： Naoko Senda ,  Yoko Inoue ,  Hiroaki Nakagawa ,  Akihiro Shimase ,  Ryota Nakajima ,  Kazumichi Imai ,  Shizu Takeda

IPC分类号： C12M1/34 ,  C12M1/36 ,  G01N33/68 ,  G01N33/50

CPC分类号： C12M41/46 ,  C12M41/48 ,  G01N33/5005 ,  G01N33/6806 ,  G01N33/6812

摘要： There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (Ile, Val, Ser, Leu, and Ala), thereby making a determination.

公开(公告)号：US20170261524A1

公开(公告)日：2017-09-14

申请号：US15450135

申请日：2017-03-06

申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD. ,  AJINOMOTO CO., INC.

发明人： Masako HAYAKAWA ,  Kazutaka SHIMBO ,  Hiroo YOSHIDA

IPC分类号： G01N33/96 ,  G01N33/68

CPC分类号： G01N33/96 ,  G01N33/6806 ,  G01N33/6848 ,  G01N2030/042 ,  G01N2496/80 ,  Y10T436/105831 ,  Y10T436/106664

摘要： An external standard solution for use in the analysis of amino acid in plasma, containing, (1) at least one amino acid selected from the following components A, at a concentration of 0.0007 M to 0.49 M, and (2) (i) at least one amino acid selected from the following components B, at a concentration of 0.2 to 0.9 times of the lowest-concentration amino acid among the amino acids selected from components A, (ii) at least one amino acid selected from the following components C, at a concentration of 0.1 to 0.4 times of the lowest-concentration amino acid among amino acids selected from the components A, or (iii) at least one amino acid selected from the following components D, at a concentration of 0.05 to 0.2 times of the lowest-concentration amino acid among amino acids selected from the components A; [Components A] valine, glycine, alanine and glutamine [Components B] serine, proline, threonine, taurine, leucine, isoleucine, lysine, histidine, phenylalanine and tyrosine [Components C] asparagine, ornithine, arginine and tryptophan [Components D] glutamic acid, methionine, citrulline and cystine.

公开(公告)号：US09638706B2

公开(公告)日：2017-05-02

申请号：US14232073

申请日：2012-07-19

申请人： Masako Hayakawa ,  Kazutaka Shimbo ,  Hiroo Yoshida

发明人： Masako Hayakawa ,  Kazutaka Shimbo ,  Hiroo Yoshida

IPC分类号： G01N33/68 ,  G01N33/96 ,  G01N30/04

CPC分类号： G01N33/96 ,  G01N33/6806 ,  G01N33/6848 ,  G01N2030/042 ,  G01N2496/80 ,  Y10T436/105831 ,  Y10T436/106664

摘要： An external standard solution for use in the analysis of amino acid in plasma, containing,(1) at least one amino acid selected from the following components A, at a concentration of 0.0007 M to 0.49 M, and (2) (i) at least one amino acid selected from the following components B, at a concentration of 0.2 to 0.9 times of the lowest-concentration amino acid among the amino acids selected from components A, (ii) at least one amino acid selected from the following components C, at a concentration of 0.1 to 0.4 times of the lowest-concentration amino acid among amino acids selected from the components A, or (iii) at least one amino acid selected from the following components D, at a concentration of 0.05 to 0.2 times of the lowest-concentration amino acid among amino acids selected from the components A; [Components A] valine, glycine, alanine and glutamine [Components B] serine, proline, threonine, taurine, leucine, isoleucine, lysine, histidine, phenylalanine and tyrosine [Components C] asparagine, ornithine, arginine and tryptophan [Components D] glutamic acid, methionine, citrulline and cystine.

公开(公告)号：US20160354436A1

公开(公告)日：2016-12-08

申请号：US15024648

申请日：2014-09-25

申请人： PRONUTRIA Biosciences, Inc.

发明人： Alison WILLIAMS ,  Nathaniel W. SILVER ,  Andrew DOWNEY ,  David V. ERBE ,  Michael J. HAMILL ,  David Arthur BERRY

IPC分类号： A61K38/17 ,  A23L33/18 ,  A23L33/00 ,  A61K38/16 ,  A23L2/66

CPC分类号： A61K38/1709 ,  A23L2/66 ,  A23L33/17 ,  A23L33/175 ,  A23L33/18 ,  A23L33/195 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/0075 ,  A61K9/0095 ,  A61K9/146 ,  A61K9/2054 ,  A61K9/2866 ,  A61K38/00 ,  A61K38/10 ,  A61K38/16 ,  A61K38/164 ,  A61K38/168 ,  A61K38/17 ,  A61K38/1703 ,  A61K38/1767 ,  A61K38/38 ,  A61K38/45 ,  A61K45/06 ,  C12Y207/04003 ,  G01N33/6803 ,  G01N33/6806 ,  G01N33/6848 ,  G01N2500/00 ,  G16B20/00

摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

摘要翻译： 本文提供营养多肽。 还提供了各种其它实施方案，包括编码多肽的核酸，制备多肽的重组微生物，用于表达多肽的载体，使用重组微生物制备多肽的方法，包含多肽的组合物和制剂，以及使用多肽的方法， 组合物和制剂。

公开(公告)号：US20160341748A1

公开(公告)日：2016-11-24

申请号：US14757179

申请日：2015-12-01

申请人： Albert B. Crum

发明人： Albert B. Crum

IPC分类号： G01N33/92 ,  G01N33/493 ,  G01N33/68

CPC分类号： G01N33/92 ,  G01N33/493 ,  G01N33/6806 ,  G01N33/6812 ,  G01N33/6815 ,  G01N2800/52 ,  G01N2800/7009

摘要： The invention relates to diagnostic methods for assessing the need of a subject for treatment with an anti-oxidant, or alternatively, for determining the utilization efficiency and ultimate effectiveness of anti-oxidant therapy in subjects having been treated with antioxidants. More specifically, the methods of the present invention are particularly useful in prophylactic assessment of individuals at risk for developing diseases or conditions in which oxidative stress plays a role, such that an appropriate therapeutic regimen can be prescribed for that individual, thus leading to alternative therapies and/or life style changes. The invention further relates to methods for assessing the need for, the utilization efficiency and the effectiveness of therapy in subjects having received therapy with specific antioxidant and immune enhancing formulations. Kits are also provided for measuring the levels of markers of oxidative stress and immune cell numbers.

摘要翻译： 本发明涉及用于评估受试者用抗氧化剂治疗的需要的诊断方法，或者用于确定已经用抗氧化剂治疗的受试者中抗氧化剂治疗的使用效率和最终有效性的诊断方法。 更具体地说，本发明的方法特别可用于预防性评估患有氧化应激发挥作用的疾病或病症风险的个体，从而可为该个体规定适当的治疗方案，从而导致替代疗法 和/或生活方式的变化。 本发明还涉及用于评估接受特定抗氧化剂和免疫增强制剂治疗的受试者的治疗需求，使用效率和疗效的方法。 还提供了用于测量氧化应激和免疫细胞数量标记物水平的试剂盒。

公开(公告)号：US09182407B2

公开(公告)日：2015-11-10

申请号：US12644798

申请日：2009-12-22

申请人： Takayuki Tanaka ,  Toshihiko Ando ,  Hiroshi Yamamoto ,  Minoru Yamakado

发明人： Takayuki Tanaka ,  Toshihiko Ando ,  Hiroshi Yamamoto ,  Minoru Yamakado

IPC分类号： G01N33/68 ,  G06F19/00

CPC分类号： G01N33/6806 ,  G01N2800/02 ,  G01N2800/04 ,  G01N2800/50 ,  G06F19/3418 ,  G16H10/40

摘要： According to the method of evaluating visceral fat accumulation of the present invention, amino acid concentration data on concentration values of amino acids in blood collected from a subject to be evaluated is measured, and a visceral fat accumulation condition in the subject is evaluated based on the measured amino acid concentration data of the subject.

摘要翻译： 根据本发明的内脏脂肪蓄积的评价方法，测定从被评价对象收集的血液中的氨基酸的浓度值的氨基酸浓度数据，并根据对象的内脏脂肪蓄积条件 测量受试者的氨基酸浓度数据。

公开(公告)号：US20150254411A1

公开(公告)日：2015-09-10

申请号：US14721439

申请日：2015-05-26

申请人： Ajinomoto Co., Inc.

发明人： Nobukazu Ono ,  Atsuko Shinhara ,  Takahiko Muramatsu ,  Shinya Kikuchi ,  Hiroshi Yamamoto ,  Koichi Shiraishi ,  Kazuhiro Katayama ,  Nobuyasu Fukutake ,  Masahiko Higashiyama ,  Shinichi Ohkawa ,  Makoto Ueno ,  Yohei Miyagi ,  Naoyuki Okamoto

IPC分类号： G06F19/00

CPC分类号： G16H50/20 ,  G01N33/57438 ,  G01N33/6806 ,  G16B99/00

摘要： A method of evaluating pancreatic cancer includes (I) an obtaining step of obtaining amino acid concentration data on a concentration value of an amino acid in blood collected from a subject to be evaluated, and (II) an evaluating step of evaluating a state of pancreatic cancer in the subject by calculating a value of a formula using the amino acid concentration data of the subject obtained at the obtaining step and the formula previously established for evaluating the state of pancreatic cancer, including an explanatory variable to be substituted with the concentration value of the amino acid. The amino acid concentration data includes the concentration values of at least two amino acids of Asn, His, Thr, Ala, Cit, Arg, Tyr, Val, Met, Lys, Trp, Gly, Pro, Orn, Ile, Leu, Phe, Ser, and Gln, and the formula includes at least two explanatory variables to be substituted with the concentration values of at least two amino acids of Asn, His, Thr, Ala, Cit, Arg, Tyr, Val, Met, Lys, Trp, Gly, Pro, Orn, Ile, Leu, Phe, Ser, and Gln.

摘要翻译： 评估胰腺癌的方法包括：（I）获得从待评价对象收集的血液中的氨基酸的浓度值的氨基酸浓度数据的获取步骤，（II）评价胰腺状态的评价步骤 通过使用在获得步骤中获得的受试者的氨基酸浓度数据和用于评估胰腺癌状态的先前建立的公式计算公式的值，包括将被替换为胰岛素的浓度值的解释变量的受试者的癌症 氨基酸。 氨基酸浓度数据包括Asn，His，Thr，Ala，Cit，Arg，Tyr，Val，Met，Lys，Trp，Gly，Pro，Orn，Ile，Leu，Phe中至少两个氨基酸的浓度值， Ser和Gln，并且该式包括至少两个解释变量，其被Asn，His，Thr，Ala，Cit，Arg，Tyr，Val，Met，Lys，Trp的至少两个氨基酸的浓度值所取代， Gly，Pro，Orn，Ile，Leu，Phe，Ser和Gln。