公开(公告)号：US20240000052A1

公开(公告)日：2024-01-04

申请号：US18345951

申请日：2023-06-30

Applicant: Kansas State University Research Foundation

Inventor： Juergen A. Richt ,  Igor Morozov ,  Bianca Artiaga ,  Taeyong Kwon

IPC: A01K67/027 ,  C12N9/76

CPC classification number: A01K67/0276 ,  C12N9/6427 ,  C12Y304/21004 ,  A01K2227/108 ,  A01K2267/02 ,  A01K2217/075

Abstract: Genetically modified transgenic pigs or pig cells having at least one knocked out Transmembrane protease, serine (TMPRSS) gene. Expression of functional gene products of the at least one knocked out TMPRSS gene in the genetically modified transgenic pig or pig cells is reduced as compared to the non-genetically modified pig or pig cells. The at least one TMPRSS gene can be knocked out using CRISPR/Cas systems.