公开(公告)号：US20040176616A1

公开(公告)日：2004-09-09

申请号：US10749806

申请日：2003-12-31

申请人： KANTO KAGAKU KABUSHIKI KAISHA

发明人： Masahito Watanabe ,  Kunihiko Murata ,  Takao Ikariya

IPC分类号： C07D335/06 ,  C07D311/04

CPC分类号： C07C67/347 ,  B01J31/1805 ,  B01J2231/348 ,  B01J2531/821 ,  B01J2540/34 ,  C07B2200/07 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C69/716

摘要： A highly efficient process is provided for producing an optically active compound having high optical purity by an asymmetric reaction using as a catalyst a transition metal complex having an optically active nitrogen-containing compound as an asymmetric ligand.

摘要翻译： 提供了一种高效的方法，通过使用具有光学活性的含氮化合物作为不对称配体的过渡金属络合物作为催化剂，通过不对称反应制备具有高光学纯度的光学活性化合物。

公开(公告)号：US20030166978A1

公开(公告)日：2003-09-04

申请号：US10330501

申请日：2002-12-27

申请人： Kanto Kagaku Kabushiki Kaisha

发明人： Kunihiko Tsutsumi ,  Kunihiko Murata ,  Takeshi Ota ,  Takao Ikariya

IPC分类号： C07C029/14 ,  C07F015/00

CPC分类号： C07F15/0053

摘要： The invention provides novel ruthenium complexes having an optically active diphosphine compound, which has asymmetry on carbon and is easy to synthesize, as the ligand and a process for preparing optically active alcoholic compounds using said complexes as the catalysts, wherein said process is the process for preparing optically active alcoholic compounds, which are excellent in terms of reactivity, enatioselectivity and the like in an asymmetric hydrogenation of carbonyl compounds compared with conventional ruthenium complex catalysts having an optically active diphosphine compound having the axial chirality or the asymmetry on carbon as the ligand. In a preferred embodiment, the invention provides an optically active ruthenium complex represented by the general formula (1) 1 wherein X and Y, which can be identical to or different from each other, represent a hydrogen atom or an anion group, R1 and R2, which can be identical to or different from each other, represent a chain or cyclic hydrocarbon group of carbon number 1 to 20, which can be substituted, R3 and R4, which can be identical to or different from each other, represent a hydrogen atom or a hydrocarbon group of carbon number 1 to 3, and R5, R6, R7 and R8, which can be identical to or different from one another, represent a hydrocarbon group of carbon number 1 to 30, which can be substituted, with the proviso that when X and Y are bromine, R1 and R2 are a methyl group, and when R3 and R4 are a hydrogen atom, at least one of R5, R6, R7 and R8is not a phenyl group.

摘要翻译： 本发明提供具有光学活性二膦化合物的新型钌络合物，其具有碳不对称性并易于合成，作为配体，以及使用所述络合物作为催化剂制备光学活性醇化合物的方法，其中所述方法是 制备光学活性醇类化合物，与具有轴向手性或碳不对称性的光学活性二膦化合物作为配体的常规钌络合物催化剂相比，在羰基化合物的不对称氢化方面具有优异的反应性，选择性等优异性。 在优选的实施方案中，本发明提供由通式（1）表示的光学活性钌络合物，其中X和Y可以相同或不同，表示氢原子或阴离子基团R1和R2， 其可以相同或不同，表示碳原子数为1〜20的可被取代的链状或环状烃基，可以相同或不同的R 3和R 4表示氢原子或 可以相同或不同的碳原子数1〜3的烃基，可以相同或不同的R5，R6，R7和R8表示可以被取代的碳数为1〜30的烃基，条件是 当X和Y是溴时，R 1和R 2是甲基，当R 3和R 4是氢原子时，R 5，R 6，R 7和R 8中的至少一个不是苯基。