公开(公告)号：US07335686B2

公开(公告)日：2008-02-26

申请号：US10747671

申请日：2003-12-30

申请人： Kanury Venkata Subba Rao ,  Mohan Ramachandran Wani ,  Venkatasamy Manivel ,  Parameswaran Perunninakulath Subrayan ,  Vinod Kumar Singh ,  Ramasamy Vijaya Anand ,  Ehrlich Desa ,  Gyan Chandra Mishra ,  Anil Chatterji

发明人： Kanury Venkata Subba Rao ,  Mohan Ramachandran Wani ,  Venkatasamy Manivel ,  Parameswaran Perunninakulath Subrayan ,  Vinod Kumar Singh ,  Ramasamy Vijaya Anand ,  Ehrlich Desa ,  Gyan Chandra Mishra ,  Anil Chatterji

IPC分类号： A61K31/195

CPC分类号： A61K31/255 ,  A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

摘要： This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula ZOC—(CRR)m—COOH, wherein: m=2, 3 or 4; Z is OH or NH2; one R in the compound is from the group consisting of SO3H, OSO3H, CH2—SO3H, CH2—OSO3H, and NHSO3H, and the remaining Rs are H or NH2, for inhibition of osteoclastogenesis.

摘要翻译： 本发明涉及可用作破骨细胞发生抑制剂的新型酸性氨基酸/二羧酸衍生物（天然氨基酸的磺酸/硫酸衍生物及其酰胺）。 本发明还提供了使用通式为ZOC-（CRR）m -COOH的新型酸性氨基酸/二羧酸衍生物的方法，其中：m = 2,3或4; Z是OH或NH 2; 该化合物中的一个R是由SO 3 H，OSO 3 H，CH 2 -SO 3， H，CH 2 -SO 2 SO 3，NHSO 3 H，剩余的R 5是H或NH 2， / SUB>，用于抑制破骨细胞发生。

公开(公告)号：US20050085546A1

公开(公告)日：2005-04-21

申请号：US10748843

申请日：2003-12-31

申请人： Anil Chatterji ,  Krishnamurthy Natarajan ,  Venkatasamy Manivel ,  Kanury Venkata Subba Rao ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa

发明人： Anil Chatterji ,  Krishnamurthy Natarajan ,  Venkatasamy Manivel ,  Kanury Venkata Subba Rao ,  Parameswaran Subrayan ,  Vinod Singh ,  Ramasamy Anand ,  Ehrlich Desa

IPC分类号： A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  A61K31/255 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

CPC分类号： A61K31/255 ,  A61K31/16 ,  A61K31/185 ,  A61K31/19 ,  A61K31/194 ,  A61K31/195 ,  C07C305/06 ,  C07C307/02 ,  C07C309/17 ,  C07C309/18

摘要： The present invention is related to compounds having general formula Z-OC (CRn1Rn2)—CO-Z wherein Z=OH or NH2 and n1=n2=1 to 8, useful for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC—CR3R4—CR2(NHR1)—COOH, ZOC—CR5R6—CR3R4—CR1(NHR2)—COOH, ZOC—CR7R8—CR5R6—CR3R4—CR1N2)—COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC—(CH2)n—CR1R2—COOH, where Z=OH or NH2; and n=1, 2, 3. The groups R1/R2=H/SO3H or OSO3H or CH2—SO3H or CH2—OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn. The composition consists of varying amounts of the above amino acid/dicarboxylic acid derivatives or their pharmaceutically acceptable alkali/alkaline earth metal salts or their salts, the processes for the preparation of the aforesaid compounds useful for the differentiation and maturation of dendritic cells.