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    Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl-thiols and -thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders
    1.
    发明授权
    Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl-thiols and -thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders 失效
    可用于治疗免疫学，炎症和过敏性疾病的取代的苯基烷基 - （哌嗪基或高哌嗪基）烷基硫醇和硫代氨基甲酸酯

    公开(公告)号：US4618677A

    公开(公告)日：1986-10-21

    申请号：US668089

    申请日：1984-11-05

    申请人： Karl D. Hargrave ,  John P. Devlin ,  Edward A. Barsumian

    发明人： Karl D. Hargrave ,  John P. Devlin ,  Edward A. Barsumian

    IPC分类号： C07D243/08 ,  C07D295/088 ,  C07D241/38 ,  A61K31/495

    CPC分类号： C07D295/088 ,  C07D243/08

    摘要： Compounds of the formula ##STR1## wherein R is hydrogen or ##STR2## A is alkyl of 1 to 8 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; phenyl; or phenyl mono-, di- or tri-substituted independently with alkyl of 1 to 4 carbon atoms, halogen, trihalomethyl, alkoxy of 1 to 3 carbon atoms, carboxylic acyl of 1 to 3 carbon atoms, carboxyl, (alkoxy of 1 to 3 carbon atoms)carbonyl, nitro, cyano or di(alkyl of 1 to 3 carbon atoms)amino;R.sub.1, R.sub.2 and R.sub.3, are independently hydrogen, halogen, alkyl of 1 to 4 carbon atoms, trihalomethyl, nitro, cyano, di(alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, alkoxy of 1 to 4 carbon atoms or hydroxyl;R.sub.4 and R.sub.5 are independently hydrogen, alkyl of 1 to 4 carbon atoms, or phenyl;R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are independently hydrogen or methyl;Y is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --;j is 0 or 1;k and m are independently 0, 1, 2, or 3, their sum being no more than 6 and must be 0 when j is 1;n is 2, 3, or 4, with the proviso that n must be 3 or 4 when R.sub.1 is hydrogen or 2-methyl, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R are each hydrogen and j, k, and m are each 0, and Y is --CH.sub.2 --; andnon-toxic, pharmaceutically acceptable acid addition salts thereof are useful for the treatment of immunological, inflammatory and allergic disorders.

    摘要翻译： 其中R是氢或者A是具有1至8个碳原子的烷基; 3至7个碳原子的环烷基; 苯基; 或独立地具有1至4个碳原子的烷基，卤素，三卤代甲基，1至3个碳原子的烷氧基，1至3个碳原子的羧基酰基，羧基（1至3个的烷氧基） 碳原子）羰基，硝基，氰基或二（1至3个碳原子的烷基）氨基; R1，R2和R3独立地是氢，卤素，1-4个碳原子的烷基，三卤甲基，硝基，氰基，二（1-4个碳原子的烷基）氨基，（1-4个碳原子的烷氧基）羰基，烷氧基 1至4个碳原子或羟基; R4和R5独立地是氢，1-4个碳原子的烷基或苯基; R6，R7，R8和R9独立地是氢或甲基; Y是-CH 2 - 或-CH 2 -CH 2 - ; j为0或1; k和m独立为0,1,2或3，它们的和不大于6，当j为1时必须为0; n为2,3或4，条件是当R1为氢或2-甲基时，n必须为3或4，R2，R3，R4，R5，R6，R7，R8，R9和R分别为氢和j ，k和m各自为0，Y为-CH 2 - ; 其无毒的药学上可接受的酸加成盐可用于治疗免疫学，炎性和过敏性疾病。

    Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl thiols and thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders
    2.
    发明授权
    Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl thiols and thiocarbamates useful for the treatment of immunological, inflammatory, and allergic disorders 失效
    可用于治疗免疫学，炎症和过敏性疾病的取代的苯基烷基 - （哌嗪基或高哌嗪基）烷基硫醇和硫代氨基甲酸酯

    公开(公告)号：US4722926A

    公开(公告)日：1988-02-02

    申请号：US889106

    申请日：1986-07-23

    申请人： Karl D. Hargrave ,  John P. Devlin ,  Edward A. Barsumian

    发明人： Karl D. Hargrave ,  John P. Devlin ,  Edward A. Barsumian

    IPC分类号： C07D241/04 ,  C07D243/08 ,  C07D295/088 ,  A61K31/33

    CPC分类号： C07D295/088 ,  C07D241/04 ,  C07D243/08

    摘要： Compounds of the formula ##STR1## wherein R is hydrogen or ##STR2## A is alkyl of 1 to 8 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; phenyl; or phenyl mono-, di- or tri-substituted independently with alkyl of 1 to 4 carbon atoms, halogen, trihalomethyl, alkoxy of 1 to 3 carbon atoms, carboxylic acyl of 1 to 3 carbon atoms, carboxyl, (alkoxy of 1 to 3 carbon atoms)carbonyl, nitro, cyano or di(alkyl of 1 to 3 carbon atoms)amino;R.sub.1, R.sub.2 and R.sub.3, are independently hydrogen, halogen, alkyl of 1 to 4 carbon atoms, trihalomethyl, nitro, cyano, di(alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, alkoxy of 1 to 4 carbon atoms or hydroxyl;R.sub.4 and R.sub.5 are independently hydrogen, alkyl of 1 to 4 carbon atoms, or phenyl;R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are independently hydrogen or methyl;Y is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --;j is 0 to 1;k and m are independently 0, 1, 2, or 3, their sum being no more than 6 and must be 0 when j is 1;n is 2, 3, or 4, with the proviso that n must be 3 or 4 when R.sub.1 is hydrogen or 2-methyl, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R are each and j, k, and m are each 0, and Y is --CH.sub.2 --;and non-toxic, pharmaceutically acceptable acid addition salts thereof are useful for the treatment of immunological, inflammatory and allergic disorders.

    摘要翻译： 其中R是氢或者A是具有1至8个碳原子的烷基; 3至7个碳原子的环烷基; 苯基; 或独立地具有1至4个碳原子的烷基，卤素，三卤代甲基，1至3个碳原子的烷氧基，1至3个碳原子的羧基酰基，羧基（1至3个的烷氧基） 碳原子）羰基，硝基，氰基或二（1至3个碳原子的烷基）氨基; R1，R2和R3独立地是氢，卤素，1-4个碳原子的烷基，三卤甲基，硝基，氰基，二（1-4个碳原子的烷基）氨基，（1-4个碳原子的烷氧基）羰基，烷氧基 1至4个碳原子或羟基; R4和R5独立地是氢，1-4个碳原子的烷基或苯基; R6，R7，R8和R9独立地是氢或甲基; Y是-CH 2 - 或-CH 2 -CH 2 - ; j为0〜1; k和m独立为0,1,2或3，它们的和不大于6，当j为1时必须为0; n为2,3或4，条件是当R1为氢或2-甲基时，n必须为3或4，R2，R3，R4，R5，R6，R7，R8，R9和R分别为和j， k和m各自为0，Y为-CH 2 - ; 其无毒的药学上可接受的酸加成盐可用于治疗免疫学，炎性和过敏性疾病。

    Bis(arylpiperazinyl)sulfur compounds
    4.
    发明授权
    Bis(arylpiperazinyl)sulfur compounds 失效
    双（芳基哌嗪基）硫化合物

    公开(公告)号：US4692448A

    公开(公告)日：1987-09-08

    申请号：US673474

    申请日：1984-11-20

    申请人： John P. Devlin ,  Karl D. Hargrave

    发明人： John P. Devlin ,  Karl D. Hargrave

    IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D295/088 ,  C07D295/10 ,  C07D403/12

    CPC分类号： C07D295/088

    摘要： Disclosed are novel bis(arylpiperazinyl)sulfur compounds represented by formula I ##STR1## wherein: R.sub.1 and R.sub.2 are each independently hydrogen, lower alkyl, halogen, nitrile or methylthio; m and n are each independently 2 or 3; and X is a dithio, thio, sulfinyl or sulfonyl and nontoxic, pharmaceutically acceptable addition salts thereof. These compounds can be used for the prevention of allergic disorders, such as asthma, rhinitis, conjunctivitis, hay fever, urticaria, food allergies, and the like.

    摘要翻译： 公开了由式I表示的新型双（芳基哌嗪基）硫化合物，其中：R 1和R 2各自独立地为氢，低级烷基，卤素，腈或甲硫基; m和n各自独立地为2或3; 并且X是二硫代，硫代，亚磺酰基或磺酰基和无毒的药学上可接受的加成盐。 这些化合物可用于预防过敏性疾病，例如哮喘，鼻炎，结膜炎，花粉症，荨麻疹，食物过敏等。

    Alkylarylketo acids
    5.
    发明授权
    Alkylarylketo acids 失效
    烷基芳基酮酸

    公开(公告)号：US5504244A

    公开(公告)日：1996-04-02

    申请号：US166401

    申请日：1993-12-14

    申请人： Karl D. Hargrave ,  John P. Devlin

    发明人： Karl D. Hargrave ,  John P. Devlin

    IPC分类号： C07C59/76 ,  C07C59/90 ,  C07C205/56 ,  C07C229/42 ,  C07D257/04 ,  C07C69/76

    CPC分类号： C07D257/04 ,  C07C205/56 ,  C07C229/42 ,  C07C59/76 ,  C07C59/90

    摘要： Disclosed are novel alkylarylketocarboxylic acids and 5-substituted tetrazoles represented by the formula ##STR1## wherein Z is aryl or an alkyl of the structure ##STR2## W is a carboxyl moiety or a tetrazole moiety bound to Z at the 5-position of the tetrazole;R.sub.1 is C.sub.4 -C.sub.12 alkyl where Z is aryl and X is oxygen or is C.sub.5 -C.sub.12 alkyl where Z is alkyl and where Z is aryl and X is a bond;R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 -C.sub.4 alkyl, hydroxy, C.sub.1 -C.sub.4 alkoxy, halogen, trihalomethyl, nitro, cyano or C.sub.1 -C.sub.4 acyl;R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl or R.sub.4 and R.sub.6 or R.sub.5 and R.sub.7 can combine to form a carbocyclic ring;X is oxygen, or a bond at the ortho or para position;m is 0, 1 or 2; andn is 0 or 1, and nontoxic, pharmaceutically acceptable addition salts and carboxylic acid esters thereof.

    摘要翻译： 公开了新的烷基芳基酮羧酸和由下式表示的5-取代的四唑：其中Z是芳基或结构的烷基W是羧基部分或在四唑的5位与Z结合的四唑部分 ; R1是C4-C12烷基，其中Z是芳基，X是氧，或者是C5-C12烷基，其中Z是烷基，Z是芳基，X是一个键; R2和R3各自独立地为氢，C1-C4烷基，羟基，C1-C4烷氧基，卤素，三卤甲基，硝基，氰基或C1-C4酰基; R4，R5，R6和R7各自独立地为氢或C1-C4烷基或R4，R6或R5和R7可以结合形成碳环; X是氧，或邻位或对位的键; m为0,1或2; 和n为0或1，以及无毒的药学上可接受的加成盐和羧酸酯。

    Microphone Mounting Apparatus
    7.
    发明申请
    Microphone Mounting Apparatus 有权
    麦克风安装装置

    公开(公告)号：US20120049025A1

    公开(公告)日：2012-03-01

    申请号：US12868520

    申请日：2010-08-25

    申请人： Jon Caleb Halverson ,  Walter Timothy Harwood ,  Paul Mark Jacobs ,  Martin K. Reiling ,  John P. Devlin ,  Gabor Zanoni

    发明人： Jon Caleb Halverson ,  Walter Timothy Harwood ,  Paul Mark Jacobs ,  Martin K. Reiling ,  John P. Devlin ,  Gabor Zanoni

    IPC分类号： F16B2/12 ,  F16B2/20 ,  F16M13/02

    CPC分类号： F16M13/02 ,  B23P11/00 ,  F16B2/12 ,  H04R1/08 ,  Y10T29/49959

    摘要： A microphone is mounted to apparatus in order to receive sound from a sound source. The apparatus has a microphone clamp to secure different microphones to a variety of musical instruments and other sound sources and may be used to directly mount a microphone to a variety of clamping surfaces. The mounting apparatus incorporates a dual jaw design to allow for easy, fast, and secure mounting to the clamping surface. The apparatus supports a quick release mechanism for easy and fast engagement and disengagement of the dual jaws, consequently reducing time needed to securely clamp and remove the mounting apparatus with the clamping surface. The release mechanism may include a dowel release having a hole through which the jaw stud is situated. The hole has two curved surfaces so that one of jaws may be moved without turning the jaw stud when the dowel release is depressed.

    摘要翻译： 麦克风安装到设备上以便从声源接收声音。 该装置具有麦克风夹，用于将不同的麦克风固定到各种乐器和其他声源，并且可以用于将麦克风直接安装到各种夹紧表面。 安装设备结合了双颚设计，可以方便，快速，牢固地安装到夹紧表面。 该装置支持快速释放机构，用于容易且快速地接合和分离双钳口，从而减少用夹紧表面牢固地夹紧和移除安装装置所需的时间。 释放机构可以包括具有孔的销钉释放件，颚钉钉穿过该孔。 该孔具有两个弯曲表面，使得当榫头释放被压下时，可以移动颚板中的一个而不转动颚式螺柱。