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公开(公告)号:US4665083A
公开(公告)日:1987-05-12
申请号:US726867
申请日:1985-04-25
申请人: Karoly Lempert , Gyula Hornyak , Ferenc Bartha , Gabor Doleschall , Jozsef Fetter , Jozsef Nyitrai , Gyula Simig , Karoly Zauer , Peter Huszthy , Antal Feller , Lujza Petocz , Eniko Szirt , Katalin Grasser , Edit Berenyi , Zsuzsanna Orr , Etelka Pjeczka
发明人: Karoly Lempert , Gyula Hornyak , Ferenc Bartha , Gabor Doleschall , Jozsef Fetter , Jozsef Nyitrai , Gyula Simig , Karoly Zauer , Peter Huszthy , Antal Feller , Lujza Petocz , Eniko Szirt , Katalin Grasser , Edit Berenyi , Zsuzsanna Orr , Etelka Pjeczka
IPC分类号: A61K31/425 , A61K31/426 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/26 , C07D277/12 , C07D277/18
CPC分类号: C07D277/18
摘要: The invention relates to novel iminothiazolidine derivatives of the formula (I), ##STR1## wherein R.sup.1 and R.sup.3 represent, independently from each other, hydrogen or lower alkyl group,R.sup.3 is nitro or amino group,R stands for halo, lower alkyl, haloalkyl, nitro, amino, hydroxy, lower alkoxy, carboxy or lower alkoxycarbonyl group, andn is 0, 1 or 2,and pharmaceutically acceptable acid addition salts thereof.The iminothiazolidine derivatives of the formula (I) possess valuable antidepressant, antiparkinsonic, antiepileptic and spasmolytic activities.
摘要翻译: 本发明涉及式(I)的新型亚氨基噻唑烷衍生物,其中R 1和R 3彼此独立地表示氢或低级烷基,R 3是硝基或氨基,R代表卤素,低级 烷基,卤代烷基,硝基,氨基,羟基,低级烷氧基,羧基或低级烷氧基羰基,n为0,1或2及其药学上可接受的酸加成盐。 式(I)的亚氨基噻唑烷衍生物具有有价值的抗抑郁药,抗帕金森病,抗癫痫和解痉作用。