Regulatory T cell mediator proteins and uses thereof
    2.
    发明授权
    Regulatory T cell mediator proteins and uses thereof 有权
    调节性T细胞介质蛋白及其用途

    公开(公告)号:US08501915B2

    公开(公告)日:2013-08-06

    申请号:US13546098

    申请日:2012-07-11

    IPC分类号: C07K16/00

    摘要: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

    摘要翻译: 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员,并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质,抗体,活化的T细胞及其使用方法。 特别是使用这些蛋白质和化合物(优选抗体)的方法,其结合或调节(激动或拮抗)这些蛋白质的活性,作为免疫调节剂和用于治疗癌症,自身免疫疾病,变态反应,感染和炎性病症,例如, 公开了多发性硬化。

    Regulatory T cell mediator proteins and uses thereof
    3.
    发明授权
    Regulatory T cell mediator proteins and uses thereof 有权
    调节性T细胞介质蛋白及其用途

    公开(公告)号:US08231872B2

    公开(公告)日:2012-07-31

    申请号:US12732371

    申请日:2010-03-26

    IPC分类号: A61K39/395

    摘要: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

    摘要翻译: 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员,并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质,抗体,活化的T细胞和使用它们的方法。 特别是使用这些蛋白质和化合物(优选抗体)的方法,其结合或调节(激动或拮抗)这些蛋白质的活性,作为免疫调节剂和用于治疗癌症,自身免疫疾病,变态反应,感染和炎性病症,例如, 公开了多发性硬化。

    Regulatory T cell mediator proteins and uses thereof
    5.
    发明授权
    Regulatory T cell mediator proteins and uses thereof 有权
    调节性T细胞介质蛋白及其用途

    公开(公告)号:US09217035B2

    公开(公告)日:2015-12-22

    申请号:US13901704

    申请日:2013-05-24

    摘要: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

    摘要翻译: 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员,并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质,抗体,活化的T细胞及其使用方法。 特别是使用这些蛋白质和化合物(优选抗体)的方法,其结合或调节(激动或拮抗)这些蛋白质的活性,作为免疫调节剂和用于治疗癌症,自身免疫疾病,变态反应,感染和炎性病症,例如, 公开了多发性硬化。

    REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    6.
    发明申请
    REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF 有权
    调节性T细胞介质蛋白及其用途

    公开(公告)号:US20120301484A1

    公开(公告)日:2012-11-29

    申请号:US13546098

    申请日:2012-07-11

    IPC分类号: C07K16/28 A61K39/395

    摘要: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed

    摘要翻译: 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员,并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质,抗体,活化的T细胞和使用它们的方法。 特别是使用这些蛋白质和化合物(优选抗体)的方法,其结合或调节(激动或拮抗)这些蛋白质的活性,作为免疫调节剂和用于治疗癌症,自身免疫疾病,变态反应,感染和炎性病症,例如, 公开了多发性硬化

    REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    7.
    发明申请
    REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF 有权
    调节性T细胞介质蛋白及其用途

    公开(公告)号:US20110027278A1

    公开(公告)日:2011-02-03

    申请号:US12732371

    申请日:2010-03-26

    摘要: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed

    摘要翻译: 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员,并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质,抗体,活化的T细胞和使用它们的方法。 特别是使用这些蛋白质和化合物(优选抗体)的方法,其结合或调节(激动或拮抗)这些蛋白质的活性,作为免疫调节剂和用于治疗癌症,自身免疫疾病,变态反应,感染和炎性病症,例如, 公开了多发性硬化

    REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    9.
    发明申请
    REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF 有权
    调节性T细胞介质蛋白及其用途

    公开(公告)号:US20140037634A1

    公开(公告)日:2014-02-06

    申请号:US13901704

    申请日:2013-05-24

    摘要: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed

    摘要翻译: 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员,并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质,抗体,活化的T细胞和使用它们的方法。 特别是使用这些蛋白质和化合物(优选抗体)的方法,其结合或调节(激动或拮抗)这些蛋白质的活性,作为免疫调节剂和用于治疗癌症,自身免疫疾病,变态反应,感染和炎性病症,例如, 公开了多发性硬化

    System and Method of Role-based Calendaring
    10.
    发明申请
    System and Method of Role-based Calendaring 审中-公开
    基于角色的日历的系统和方法

    公开(公告)号:US20090048893A1

    公开(公告)日:2009-02-19

    申请号:US12120423

    申请日:2008-05-14

    IPC分类号: G06Q10/00

    CPC分类号: G06Q10/109 G06Q10/1093

    摘要: A method for calendaring an activity based on roles, including the steps of acquiring a request for calendaring the activity for a plurality of roles invited to attend the activity; acquiring data on existing activities which have been calendared for all the specific individuals in the plurality of roles invited to attend the activity; and determining the time interval for holding the activity based on the data on existing activities which have been calendared for all the specific individuals in the plurality of roles invited to attend the activity and the request for calendaring the activity.

    摘要翻译: 一种用于基于角色对活动进行日程安排的方法,包括获取对被邀请参加该活动的多个角色的活动的日历请求的步骤; 获取被邀请参加活动的多个角色中针对所有具体个人进行的已登录活动的数据; 以及基于被邀请参加活动的多个角色中的所有特定个人已经被日历的已有活动的数据以及对活动进行日程安排的请求,确定保持活动的时间间隔。