公开(公告)号：US20100173324A1

公开(公告)日：2010-07-08

申请号：US12494827

申请日：2009-06-30

申请人： Katsuhiro MORI ,  Naoko HIURA ,  Tsuguo KUBOTA ,  Akiko FURUYA ,  Yutaka KANDA ,  Mitsuo SATOH

发明人： Katsuhiro MORI ,  Naoko HIURA ,  Tsuguo KUBOTA ,  Akiko FURUYA ,  Yutaka KANDA ,  Mitsuo SATOH

IPC分类号： G01N33/53 ,  C07K16/18 ,  C12P21/08 ,  C12N5/16 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/06

CPC分类号： G01N33/57484 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/734 ,  C07K2317/92 ,  C12R1/91 ,  G01N33/6863 ,  G01N2333/70578 ,  G01N2400/02 ,  G01N2800/347

摘要： The present invention provides a monoclonal antibody which specifically recognizes CD27 containing an O-linked sugar chain to which galactose is not bound and binds to its extracellular region, or a method for using the same.The present invention can provide a monoclonal antibody or an antibody fragment thereof, which specifically recognizes a polypeptide encoded by CD27 gene containing an O-linked sugar chain to which galactose is not bound, and binds to its extracellular region; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which comprises the DNA; a transformant obtainable by transforming the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a diagnostic agent or a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

摘要翻译： 本发明提供一种单克隆抗体，其特异性识别含有O-连接的糖链的CD27，其中半乳糖不结合并结合到其胞外区域，或其使用方法。 本发明可以提供一种单克隆抗体或其抗体片段，该单克隆抗体或其抗体片段特异性识别由含有O-连接的糖链的CD27基因编码的多肽，其中半乳糖未结合到其上并结合其胞外区域; 产生抗体的杂交瘤; 编码抗体的DNA; 包含DNA的载体; 通过转化载体可获得的转化体; 使用杂交瘤或转化体生产抗体或其抗体片段的方法; 以及包含该抗体或其抗体片段作为有效成分的诊断剂或治疗剂。