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    Pyrrolidine derivatives having inhibitory action for proline specific endopepidase
    1.
    发明授权
    Pyrrolidine derivatives having inhibitory action for proline specific endopepidase 失效
    对脯氨酸特异性内肽酶具有抑制作用的吡咯烷衍生物

    公开(公告)号：US4880827A

    公开(公告)日：1989-11-14

    申请号：US25664

    申请日：1987-03-13

    申请人： Katsumi Tamoto ,  Renzo Ohuchi ,  Keiichi Ono

    发明人： Katsumi Tamoto ,  Renzo Ohuchi ,  Keiichi Ono

    IPC分类号： C07D207/08

    CPC分类号： C07D207/08

    摘要： Pyrrolidine derivatives having inhibitory action for proline-specific endopeptidase which are useful for anti-amnestic agent. The disclosed pyrrolidine derivatives as well as their acid addition salts can be administered orally or parenterally in the form of conventional pharmaceutical preparations. For instance, they can be administered orally in the form of conventional solid pharmaceutical preparations such as tablets, capsules, syrups and suspensions. Alternatively, they can be administered parenterally by injection in the form of conventional liquid pharmaceutical preparations such as solutions, emulsions, suspensions, etc. Also, they may be directly applied to rectum in the form of suppository. Further, the preparations may contain physiologically acceptable carriers, excipients, activators, binding agents, stabilizers, etc. In the case of injections, physiologically acceptable buffers, solubilizing agents or isotonic agents may be incorporated therein. Methods of production are also disclosed.

    摘要翻译： 具有抑制脯氨酸特异性内肽酶的作用的吡咯烷衍生物可用于抗惊厥剂。 公开的吡咯烷衍生物及其酸加成盐可以以常规药物制剂的形式口服或肠胃外给药。 例如，它们可以以常规固体药物制剂如片剂，胶囊，糖浆和悬浮液的形式口服给药。 或者，它们可以以常规液体药物制剂如溶液，乳剂，悬浮液等的形式通过注射肠胃外给药。此外，它们可以以栓剂的形式直接施用于直肠。 此外，制剂可以含有生理上可接受的载体，赋形剂，活化剂，结合剂，稳定剂等。在注射的情况下，可以加入生理上可接受的缓冲剂，增溶剂或等渗剂。 还公开了生产方法。