公开(公告)号：US20220151927A1

公开(公告)日：2022-05-19

申请号：US17529930

申请日：2021-11-18

申请人： Kaushal Rege ,  Rajeshwar Nitiyanandan ,  Tanya Nanda

发明人： Kaushal Rege ,  Rajeshwar Nitiyanandan ,  Tanya Nanda

IPC分类号： A61K9/127 ,  A61K35/12

摘要： The instant disclosure is directed to compositions comprising an encapsulated spheroid, and methods of making and using the same. A composition may comprise a spheroid comprising a plurality of cells and aminoglycoside antibiotic-derived hydrogel beads, wherein the spheroid is encapsulated by the aminoglycoside antibiotic-derived hydrogel beads to form an encapsulated spheroid. A method may comprise administering the composition to a subject in need thereof. Another method may comprise administering a compound to the encapsulated spheroid. A method of creating an encapsulated spheroid may comprise coating a surface with an aminoglycoside antibiotic-derived hydrogel, culturing a plurality of cells on the surface, thereby creating a spheroid, and encapsulating the spheroid with a plurality of aminoglycoside antibiotic-derived hydrogel beads.