公开(公告)号：US20110275827A1

公开(公告)日：2011-11-10

申请号：US13188819

申请日：2011-07-22

申请人： Kazuhiko KATO ,  Yushi KITAMURA

发明人： Kazuhiko KATO ,  Yushi KITAMURA

IPC分类号： C07D285/135

CPC分类号： C07D285/13 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  C07D285/135

摘要： A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, —C(═W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents —C(═Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.

公开(公告)号：US20110004000A1

公开(公告)日：2011-01-06

申请号：US12883338

申请日：2010-09-16

申请人： Chikara MURAKATA ,  Yoshinori YAMASHITA ,  Ryuichiro NAKAI ,  Kazuhito AKASAKA ,  Yoji INO ,  Kazuhiko KATO ,  Yushi KITAMURA

发明人： Chikara MURAKATA ,  Yoshinori YAMASHITA ,  Ryuichiro NAKAI ,  Kazuhito AKASAKA ,  Yoji INO ,  Kazuhiko KATO ,  Yushi KITAMURA

IPC分类号： C07D285/135

CPC分类号： C07D285/13 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  C07D285/135

摘要： A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, —C(═W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents —C(═Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.

摘要翻译： 一种有丝分裂驱动蛋白Eg5抑制剂，其包含由通式（I）表示的噻二唑啉衍生物或其药理学上可接受的盐作为活性成分：[其中R 1表示氢原子等，R 2表示氢原子，-C（= W）R6（其中W表示氧原子或硫原子，R6表示取代或未取代的低级烷基等）等，R3表示-C（= Z）R19（其中Z表示氧原子或硫原子 原子，R 19表示取代或未取代的低级烷基等）等，R 4表示取代或未取代的低级烷基等，R 5表示取代或未取代的芳基等〕等。