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1.发明申请ANIONIC POLYMER, POLYION COMPLEX AND TERNARY POLYMER COMPOSITE USING ANIONIC POLYMER, AND PHARMACEUTICAL COMPOSITION 有权使用阴离子聚合物和药物组合物的阴离子聚合物，聚合物和季铵盐聚合物复合物公开(公告)号：US20120196810A1
公开(公告)日：2012-08-02
申请号：US13386554
申请日：2010-07-23
申请人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
发明人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
CPC分类号： C08L79/02 , C08G69/10 , C08G73/0206 , C08G73/028 , C08L77/04
摘要： There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: -A-B—X where : A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer.
摘要翻译： 提供阴离子聚合物，聚离子络合物和三元聚合物复合材料，其中每一种在生物环境中都是稳定的并且能够实现小的RNA递送而不引起任何不期望的免疫应答。 根据本发明实施方案的阴离子聚合物包括：主链，其包含具有羧基的重复单元; 和与主链中部分羧基连接并由下式表示的侧链：-A-B-X其中：A表示具有一个或多个氨基乙基的残基; B代表体内可剪切键; X表示小RNA。 根据本发明实施方案的聚离子络合物包括如上所述的阴离子聚合物和阳离子聚合物。 根据本发明实施方案的三元聚合物复合物包括如上所述的聚离子络合物和电荷转移聚合物。
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2.发明授权Anionic polymer, polyion complex and ternary polymer composite using anionic polymer, and pharmaceutical composition 有权阴离子聚合物，聚离子络合物和三元聚合物复合材料使用阴离子聚合物，以及药物组成公开(公告)号：US08450282B2
公开(公告)日：2013-05-28
申请号：US13386554
申请日：2010-07-23
申请人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
发明人： Kazunori Kataoka , Atsushi Ishii , Hiroyasu Takemoto , Masataka Nakanishi , Nobuhiro Nishiyama , Kanjiro Miyata
IPC分类号： A61K38/00 , C07K14/72 , C07K14/705
CPC分类号： C08L79/02 , C08G69/10 , C08G73/0206 , C08G73/028 , C08L77/04
摘要： There are provided an anionic polymer, a polyion complex, and a ternary polymer composite, each of which is stable in a biological environment and is capable of realizing small RNA delivery without causing any undesired immune response. An anionic polymer according to an embodiment of the invention includes: a main chain which includes repeating units having carboxyl groups; and a side chain which is linked with part of the carboxyl groups in the main chain and is represented by the following formula: -A-B—X where: A represents a residue having one or more aminoethyl bonds; B represents an in vivo cleavable bond; and X represents a small RNA. A polyion complex according to an embodiment of the invention includes the anionic polymer as described above and a cationic polymer. A ternary polymer composite according to an embodiment of the invention includes the polyion complex as described above and a charge conversional polymer.
摘要翻译： 提供阴离子聚合物，聚离子络合物和三元聚合物复合材料，其中每一种在生物环境中都是稳定的并且能够实现小的RNA递送而不引起任何不期望的免疫应答。 根据本发明实施方案的阴离子聚合物包括：主链，其包含具有羧基的重复单元; 和与主链中部分羧基连接并由下式表示的侧链：-A-B-X其中：A表示具有一个或多个氨基乙基的残基; B代表体内可剪切键; X表示小RNA。 根据本发明实施方案的聚离子络合物包括如上所述的阴离子聚合物和阳离子聚合物。 根据本发明实施方案的三元聚合物复合物包括如上所述的聚离子络合物和电荷转移聚合物。
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3.发明授权Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof 有权包括不带电荷的亲水嵌段和在一部分侧链具有疏水基团的阳离子聚氨基酸嵌段的共聚物及其用途公开(公告)号：US08431545B2
公开(公告)日：2013-04-30
申请号：US12922116
申请日：2009-03-06
申请人： Kazunori Kataoka , Nobuhiro Nishiyama , Atsushi Ishii , Yasuki Kato , Kanjiro Miyata , Hyunjin Kim , Hiroyasu Takemoto
发明人： Kazunori Kataoka , Nobuhiro Nishiyama , Atsushi Ishii , Yasuki Kato , Kanjiro Miyata , Hyunjin Kim , Hiroyasu Takemoto
CPC分类号： C08G69/10 , C08G81/00 , Y10T428/2982
摘要： The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic group is covalently bound to the side chains of not less than 10% and not greater than 70% of amino acid repeating units in the polyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, a small-molecule nucleic acid, under a physiological condition.
摘要翻译： 本发明涉及含有不带电荷的亲水性聚合物链段和阳离子聚氨基酸链嵌段的嵌段共聚物，其中亲水性聚合物链嵌段共价键合到聚氨基酸链嵌段的主链的一端，疏水基 与聚氨基酸链嵌段中氨基酸重复单元的侧链共价结合不少于10％且不大于70％。 该嵌段共聚物在生理条件下与siRNA（小分子核酸）形成稳定的聚集体。
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4.发明申请公开(公告)号：US20110052917A1
公开(公告)日：2011-03-03
申请号：US12922116
申请日：2009-03-06
申请人： Kazunori Kataoka , Nobuhiro Nishiyama , Atsushi Ishii , Yasuki Kato , Kanjiro Miyata , Hyunjin Kim , Hiroyasu Takemoto
发明人： Kazunori Kataoka , Nobuhiro Nishiyama , Atsushi Ishii , Yasuki Kato , Kanjiro Miyata , Hyunjin Kim , Hiroyasu Takemoto
CPC分类号： C08G69/10 , C08G81/00 , Y10T428/2982
摘要： The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is covalently bound to one end of the main chain of the polyamino acid chain block, and the hydrophobic group is covalently bound to the side chains of not less than 10% and not greater than 70% of amino acid repeating units in the polyamino acid chain block. This block copolymer forms a stable aggregate with siRNA, a small-molecule nucleic acid, under a physiological condition.
摘要翻译： 本发明涉及含有不带电荷的亲水性聚合物链段和阳离子聚氨基酸链嵌段的嵌段共聚物，其中亲水性聚合物链嵌段共价键合到聚氨基酸链嵌段的主链的一端，疏水基 与聚氨基酸链嵌段中氨基酸重复单元的侧链共价结合不少于10％且不大于70％。 该嵌段共聚物在生理条件下与siRNA（小分子核酸）形成稳定的聚集体。
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