公开(公告)号：US5945404A

公开(公告)日：1999-08-31

申请号：US927399

申请日：1997-09-10

申请人： Kei Sugai ,  Motoaki Goto ,  Satoshi Yoshida ,  Yumiko Noda ,  Takayuki Ishii ,  Nobuyuki Kibushi ,  Hutoshi Nishikawa

发明人： Kei Sugai ,  Motoaki Goto ,  Satoshi Yoshida ,  Yumiko Noda ,  Takayuki Ishii ,  Nobuyuki Kibushi ,  Hutoshi Nishikawa

IPC分类号： C07J17/00 ,  C07J41/00 ,  C07J43/00 ,  A61K31/705 ,  C07J5/00 ,  C07J7/00 ,  C07J9/00

CPC分类号： C07J43/003 ,  C07J17/005 ,  C07J41/005

摘要： A glycoside represented by formula (I), wherein dexamethasone or betamethasone is the aglycon and the 21-position is substituted by a simple sugar or an acylated sugar selected from the group consisting of glucose, galactose, mannose, rhamnose, fucose, N-acetylglucosamine, N-acetylgalactosamine, galacturonic acid, glucuronic acid and sialic acid. ##STR1##

摘要翻译： 由式（I）表示的糖苷，其中地塞米松或倍他米松是糖苷配基，21位被选自葡萄糖，半乳糖，甘露糖，鼠李糖，岩藻糖，N-乙酰葡糖胺的单糖或酰化糖取代 ，N-乙酰半乳糖胺，半乳糖醛酸，葡糖醛酸和唾液酸。

公开(公告)号：US5231177A

公开(公告)日：1993-07-27

申请号：US488860

申请日：1990-03-05

申请人： Kinichi Saito ,  Hideo Mizu ,  Naokazu Sugiyama ,  Shikoh Minagawa ,  Motoaki Goto ,  Kenji Abiko

发明人： Kinichi Saito ,  Hideo Mizu ,  Naokazu Sugiyama ,  Shikoh Minagawa ,  Motoaki Goto ,  Kenji Abiko

IPC分类号： C07H13/06 ,  A61K31/70 ,  A61K31/7024 ,  A61P11/10 ,  C07H13/04

CPC分类号： C07H13/04

摘要： Sodium N-acetylneuraminate trihydrate herein provided is represented by the following formula: ##STR1## The sodium N-acetylneuraminate trihydrate can be prepared, for instance, according to a method which comprises the steps of: dissolving sodium N-acetylneuraminate in water or in a mixture of water and an organic solvent; allowing the resulting solution to stand; precipitating and separating the resulting crystals of sodium N-acetylneuraminate.trihydrate; and then drying the separated crystals. The sodium N-acetylneuraminate trihydrate has very low hygroscopicity and hence can be handled without any difficulty in the form of powder.