公开(公告)号：US09586921B2

公开(公告)日：2017-03-07

申请号：US13260506

申请日：2010-02-05

申请人： Keiichi Yamamoto ,  Toshiki Okubo ,  Satoshi Yomoda ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

发明人： Keiichi Yamamoto ,  Toshiki Okubo ,  Satoshi Yomoda ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

IPC分类号： A61K31/365 ,  C07D307/33 ,  A61K9/16 ,  A61K9/20 ,  A61K36/28 ,  A61K9/19

CPC分类号： C07D307/33 ,  A61K9/1623 ,  A61K9/1688 ,  A61K9/19 ,  A61K9/2054 ,  A61K31/365 ,  A61K36/28

摘要： PROBLEM TO BE SOLVEDA burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for treatment of pancreatic cancer.SOLUTIONThe burdock fruit extract containing arctigenin at high content by enzymatically converted arctiin into arctigenin with beta-glucosidase, which is an enzyme occurring endogenously in a burdock fruit, and adding ethanol, extracting, concentrating and then freeze-drying or spray drying.

摘要翻译： 牛蒡果实提取物含有高含量的玉米黄质素，通过酶法转化成arctinin，以β-葡萄糖苷酶为主要成分，其中β-葡糖苷酶是在牛蒡果实内生发酵的酶，加入乙醇，萃取，浓缩，然后冷冻干燥或喷雾干燥。

公开(公告)号：US20120029070A1

公开(公告)日：2012-02-02

申请号：US13260506

申请日：2010-02-05

申请人： Keiichi Yamamoto ,  Toshiki Okubo ,  Satoshi Yomoda ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

发明人： Keiichi Yamamoto ,  Toshiki Okubo ,  Satoshi Yomoda ,  Hiroyasu Esumi ,  Chika Miyoshi ,  Shigetoshi Kadota

IPC分类号： A61K31/365 ,  A61P35/00 ,  C12P17/04

CPC分类号： C07D307/33 ,  A61K9/1623 ,  A61K9/1688 ,  A61K9/19 ,  A61K9/2054 ,  A61K31/365 ,  A61K36/28

摘要： PROBLEM TO BE SOLVEDA burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for treatment of pancreatic cancer.SOLUTIONThe burdock fruit extract containing arctigenin at high content by enzymatically converted arctiin into arctigenin with beta-glucosidase, which is an enzyme occurring endogenously in a burdock fruit, and adding ethanol, extracting, concentrating and then freeze-drying or spray drying.

摘要翻译： 待解决的问题提供含有高含量的牛蒡子黄素的牛蒡果实提取物及其制备方法，其均用于治疗胰腺癌。 解决方案：牛蒡果实提取物含有高含量的玉米赤霉素，通过酶法转化成arctigenin与β-葡萄糖苷酶，其是在牛蒡果实内生发酵的酶，并加入乙醇，提取，浓缩，然后冷冻干燥或喷雾干燥。

公开(公告)号：US07550436B2

公开(公告)日：2009-06-23

申请号：US10258420

申请日：2001-05-08

申请人： Ryuji Takahashi ,  Satoshi Yomoda

发明人： Ryuji Takahashi ,  Satoshi Yomoda

IPC分类号： A61K38/10 ,  G01N33/53

CPC分类号： A61K38/018 ,  A23L33/18

摘要： A composition containing a peptide and an electrolyte excretion promoter, which comprises a peptide or a peptide mixture which is obtained by lysing a food-origin protein with a protease and has an activity of inhibiting angiotensin converting enzyme, and one or more electrolyte excretion promoters selected from chitosan, alginic acid or a salt thereof, and further relates to a food containing the same. Said composition has excellent inhibitory activity to rise of blood pressure by synergistic effects of both components.

摘要翻译： 含有肽和电解质排泄促进剂的组合物，其包含通过用蛋白酶裂解食源性蛋白质并具有抑制血管紧张素转化酶的活性而获得的肽或肽混合物，以及选择的一种或多种电解质排泄促进剂 来自壳聚糖，藻酸或其盐，并且还涉及含有该壳聚糖的食品。 所述组合物通过两种组分的协同效应对血压升高具有优异的抑制活性。