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公开(公告)号：USD448328S1
公开(公告)日：2001-09-25
申请号：US29126203
申请日：2000-07-11
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公开(公告)号：USD449801S1
公开(公告)日：2001-10-30
申请号：US29126207
申请日：2000-07-11
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公开(公告)号：USD429190S
公开(公告)日：2000-08-08
申请号：US112892
申请日：1999-10-26
申请人： Christopher T. Baker
设计人： Christopher T. Baker
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公开(公告)号：USD430828S
公开(公告)日：2000-09-12
申请号：US116198
申请日：1999-12-28
申请人： Christopher T. Baker
设计人： Christopher T. Baker
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公开(公告)号：USD429191S
公开(公告)日：2000-08-08
申请号：US116194
申请日：1999-12-28
申请人： Christopher T. Baker
设计人： Christopher T. Baker
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公开(公告)号：US20090042973A1
公开(公告)日：2009-02-12
申请号：US12217517
申请日：2008-07-02
申请人： Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
发明人： Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
IPC分类号： A61K31/343 , C07C255/03 , C07D307/78 , A61K31/352 , A61P31/18 , C07D319/16 , A61K31/277
CPC分类号： C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C317/18 , C07D307/20 , C07D319/06 , C07D493/04 , C07F9/6561
摘要： The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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公开(公告)号：US06617350B2
公开(公告)日：2003-09-09
申请号：US09927271
申请日：2001-08-09
申请人： Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , François Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
发明人： Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , François Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
IPC分类号： A61K3134
CPC分类号： C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C317/18 , C07D307/20 , C07D319/06 , C07D493/04 , C07F9/6561
摘要： The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
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公开(公告)号：USD432060S
公开(公告)日：2000-10-17
申请号：US116796
申请日：2000-01-11
申请人： Christopher T. Baker
设计人： Christopher T. Baker
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公开(公告)号：USD430518S
公开(公告)日：2000-09-05
申请号：US116197
申请日：1999-12-28
申请人： Christopher T. Baker
设计人： Christopher T. Baker
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公开(公告)号：US07919523B2
公开(公告)日：2011-04-05
申请号：US12217517
申请日：2008-07-02
申请人： Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
发明人： Michael R. Hale , Christopher T. Baker , Timothy A. Stammers , Ronald George Sherrill , Andrew Spaltenstein , Eric Steven Furfine , Francois Maltais , Clarence Webster Andrews, III , John Franklin Miller , Vicente Samano
IPC分类号： A61K31/357 , C07D319/06
CPC分类号： C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C317/18 , C07D307/20 , C07D319/06 , C07D493/04 , C07F9/6561
摘要： The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.
摘要翻译： 本发明涉及一类新型的磺酰胺，它们是天冬氨酰蛋白酶抑制剂。 在一个实施方案中，本发明涉及以特定结构和物理化学特征为特征的新型HIV天冬氨酰蛋白酶抑制剂。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制HIV-1和HIV-2蛋白酶活性，因此可有利地用作针对HIV-1和HIV-2病毒的抗病毒剂。 本发明还涉及使用本发明化合物抑制HIV天冬氨酰蛋白酶活性的方法和用于筛选抗HIV活性化合物的方法。
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