公开(公告)号：US08906666B2

公开(公告)日：2014-12-09

申请号：US12994100

申请日：2009-05-22

申请人： Keith Alsaker ,  Daniel Grenfell-Lee ,  Michael Hudson ,  Adam Lawrence ,  Jessica McGrath ,  David Young

发明人： Keith Alsaker ,  Daniel Grenfell-Lee ,  Michael Hudson ,  Adam Lawrence ,  Jessica McGrath ,  David Young

IPC分类号： C12N1/21 ,  C12N1/19 ,  C12P7/16 ,  C12N1/36 ,  C12N15/52

CPC分类号： C12P7/16 ,  C12N1/36 ,  C12N15/52 ,  Y02E50/10

摘要： The present disclosure provides improved systems for the biological production of aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in some embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. In one aspect, the present disclosure provides engineered microorganisms that both produce an aliphatic alcohol compound and show resistance to that compound as measured by an ability to grow to predetermined levels in the presence of a given concentration of the compound.

摘要翻译： 本公开提供了用于脂族醇化合物的生物制备的改进的系统。 特别地，本公开提供了显示改善的抗脂肪醇毒性的生物系统; 在一些实施方案中，这种改进的抗性允许增加脂族醇生产水平。 在一个方面，本公开提供了工程化的微生物，其既产生脂族醇化合物，并且在给定浓度的化合物存在下通过生长至预定水平的能力来测量该化合物的抗性。

公开(公告)号：US20120040440A1

公开(公告)日：2012-02-16

申请号：US12994100

申请日：2009-05-22

申请人： Keith Alsaker ,  Daniel Grenfell-Lee ,  Michael Hudson ,  Adam Lawrence ,  Jessica McGrath ,  David Young

发明人： Keith Alsaker ,  Daniel Grenfell-Lee ,  Michael Hudson ,  Adam Lawrence ,  Jessica McGrath ,  David Young

IPC分类号： C12N1/21 ,  C12N1/19

CPC分类号： C12P7/16 ,  C12N1/36 ,  C12N15/52 ,  Y02E50/10

摘要： The present disclosure provides improved systems for the biological production of aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in some embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. In one aspect, the present disclosure provides engineered microorganisms that both produce an aliphatic alcohol compound and show resistance to that compound as measured by an ability to grow to predetermined levels in the presence of a given concentration of the compound.

摘要翻译： 本公开提供了用于脂族醇化合物的生物制备的改进的系统。 特别地，本公开提供了显示改善的抗脂肪醇毒性的生物系统; 在一些实施方案中，这种改进的抗性允许增加脂族醇生产水平。 在一个方面，本公开提供了工程化的微生物，其既产生脂族醇化合物，并且在给定浓度的化合物存在下通过生长至预定水平的能力来测量该化合物的抗性。

公开(公告)号：US20120058541A1

公开(公告)日：2012-03-08

申请号：US13214310

申请日：2011-08-22

申请人： Keith Alsaker ,  Daniel Grenfell-Lee ,  Michael Hudson ,  Adam Lawrence ,  Jessica McGrath ,  David Young

发明人： Keith Alsaker ,  Daniel Grenfell-Lee ,  Michael Hudson ,  Adam Lawrence ,  Jessica McGrath ,  David Young

IPC分类号： C12N1/21 ,  C12N1/19

CPC分类号： C12N9/52 ,  C12P7/16 ,  Y02E50/10

摘要： The present disclosure provides improved systems for the biological production of certain aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved resistance to aliphatic alcohol toxicity; in sonic embodiments, such improved resistance allows for increased levels of aliphatic alcohol production. Accordingly, the present disclosure provides, inter alia, engineered microorganisms that both produce an aliphatic alcohol compound and show resistance to that compound as measured by an ability to grow to predetermined levels in the presence of a given concentration of the compound.

摘要翻译： 本公开提供了用于某些脂族醇化合物的生物制备的改进的系统。 特别地，本公开提供了显示改善的抗脂肪醇毒性的生物系统; 在声音实施例中，这种改进的电阻允许增加脂族醇生产的水平。 因此，本公开尤其提供了工程化的微生物，它们都产生脂族醇化合物，并且通过在给定浓度的化合物的存在下生长至预定水平的能力来测量该化合物的抗性。