公开(公告)号：US20190192670A1

公开(公告)日：2019-06-27

申请号：US16290496

申请日：2019-03-01

申请人： KemPharm, Inc.

发明人： Travis Mickle ,  Sven Guenther ,  Guochen Chi ,  Jaroslaw Kanski ,  Andrea K Martin ,  Bindu Bera

IPC分类号： A61K47/55 ,  A61K47/54 ,  A61K9/00 ,  A61K31/485 ,  A61K31/616 ,  A61K31/185

CPC分类号： A61K47/55 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K31/185 ,  A61K31/485 ,  A61K31/616 ,  A61K31/70 ,  A61K47/542

摘要： The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

公开(公告)号：US10441661B2

公开(公告)日：2019-10-15

申请号：US16290496

申请日：2019-03-01

申请人： KemPharm, Inc.

发明人： Travis Mickle ,  Sven Guenther ,  Guochen Chi ,  Jaroslaw Kanski ,  Andrea K Martin ,  Bindu Bera

IPC分类号： C07D489/02 ,  A61K31/485 ,  A61K47/55 ,  A61K47/54 ,  A61K9/00 ,  A61K31/616 ,  A61K31/185 ,  A61K31/70

摘要： The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.