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1.发明申请INHIBITOR SCREENING METHOD AND ATOPIC DERMATITIS LIKE SYMPTOM INDUCING METHOD WHICH UTILIZES INDUCTION OF PRODUCTION OF INTERLEUKIN 18 BY KERATINOCYTE AND UTILIZATION OF SAME 失效抑制剂筛选方法和目的药物类似于利用克拉霉素诱导白细胞介素18诱导产生的症状诱导方法及其利用公开(公告)号：US20100003194A1
公开(公告)日：2010-01-07
申请号：US12499231
申请日：2009-07-08
CPC分类号： G01N33/5044 , C07K14/54 , G01N33/5008 , G01N33/5023 , G01N33/5088 , G01N33/6854 , G01N2333/54
摘要： The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocyte (KC), and their usages. The methods are preferably applicable for understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying, on skin of mice or the like, protein A (SpA) derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to high level in serum, which elevation is generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.
摘要翻译： 本发明提供了使用来自角质形成细胞（KC）的白细胞介素18（IL-18）的产生诱导现象及其用途的方法。 该方法优选适用于了解特应性皮炎（AD）和AD样症状的致病机制，以及用于开发用于AD和AD样症状的治疗药物。 例如，通过在小鼠等皮肤上施用衍生自金黄色葡萄球菌的蛋白A（SpA）或在小鼠上移植已经发展为AD的炎症性皮肤病的皮肤移植物，可以再现高度 血清中IgE达到高水平，在AD样病变中产生升高。 结果，例如可以筛选抑制KC诱导IL-18产生的抑制剂。
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2.发明授权Inhibitor screening method and atopic dermatitis like symptom inducing method which utilizes induction of production of interleukin 18 by keratinocyte and utilization of same 失效抑制剂筛选方法和特应性皮炎，如通过角质形成细胞诱导产生白细胞介素18并利用其的症状诱导方法公开(公告)号：US08293212B2
公开(公告)日：2012-10-23
申请号：US12499231
申请日：2009-07-08
CPC分类号： G01N33/5044 , C07K14/54 , G01N33/5008 , G01N33/5023 , G01N33/5088 , G01N33/6854 , G01N2333/54
摘要： The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocyte (KC), and their usages. The methods are preferably applicable for understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying, on skin of mice or the like, protein A (SpA) derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to high level in serum, which elevation is generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.
摘要翻译： 本发明提供了使用来自角质形成细胞（KC）的白细胞介素18（IL-18）的产生诱导现象及其用途的方法。 该方法优选适用于了解特应性皮炎（AD）和AD样症状的致病机制，以及用于开发用于AD和AD样症状的治疗药物。 例如，通过在小鼠等皮肤上施用衍生自金黄色葡萄球菌的蛋白A（SpA）或在小鼠上移植已经发展为AD的炎症性皮肤病的皮肤移植物，可以再现高度 血清中IgE达到高水平，在AD样病变中产生升高。 结果，例如可以筛选抑制KC诱导IL-18产生的抑制剂。
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3.发明申请Inhibitor screening method and atopic dermatitis-like symptom inducing method which utilizes induction of production of interleukin 18 by keratinocyte and utilization of same 审中-公开抑制剂筛选方法和特应性皮炎样症状诱导方法，其利用角质形成细胞诱导产生白细胞介素18并利用其公开(公告)号：US20070092448A1
公开(公告)日：2007-04-26
申请号：US10554301
申请日：2004-04-21
CPC分类号： G01N33/5044 , C07K14/54 , G01N33/5008 , G01N33/5023 , G01N33/5088 , G01N33/6854 , G01N2333/54
摘要： The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocyte (KC), and their usages. The methods are preferably applicable for understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying, on skin of mice or the like, protein. A (SpA) derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to high level in serum, which elevation is generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.
摘要翻译： 本发明提供了使用来自角质形成细胞（KC）的白细胞介素18（IL-18）的产生诱导现象及其用途的方法。 该方法优选适用于了解特应性皮炎（AD）和AD样症状的致病机制，以及用于开发用于AD和AD样症状的治疗药物。 例如，通过在小鼠等的皮肤上施用蛋白质。 来自金黄色葡萄球菌的A（SpA）或在小鼠上移植已经发展为AD的炎性皮肤病的皮肤移植物，可以将血清中IgE升高到高水平，这可以在AD- 像病变。 结果，例如可以筛选抑制KC诱导IL-18产生的抑制剂。
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