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1.发明申请INHIBITOR SCREENING METHOD AND ATOPIC DERMATITIS LIKE SYMPTOM INDUCING METHOD WHICH UTILIZES INDUCTION OF PRODUCTION OF INTERLEUKIN 18 BY KERATINOCYTE AND UTILIZATION OF SAME 失效抑制剂筛选方法和目的药物类似于利用克拉霉素诱导白细胞介素18诱导产生的症状诱导方法及其利用公开(公告)号：US20100003194A1
公开(公告)日：2010-01-07
申请号：US12499231
申请日：2009-07-08
CPC分类号： G01N33/5044 , C07K14/54 , G01N33/5008 , G01N33/5023 , G01N33/5088 , G01N33/6854 , G01N2333/54
摘要： The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocyte (KC), and their usages. The methods are preferably applicable for understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying, on skin of mice or the like, protein A (SpA) derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to high level in serum, which elevation is generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.
摘要翻译： 本发明提供了使用来自角质形成细胞（KC）的白细胞介素18（IL-18）的产生诱导现象及其用途的方法。 该方法优选适用于了解特应性皮炎（AD）和AD样症状的致病机制，以及用于开发用于AD和AD样症状的治疗药物。 例如，通过在小鼠等皮肤上施用衍生自金黄色葡萄球菌的蛋白A（SpA）或在小鼠上移植已经发展为AD的炎症性皮肤病的皮肤移植物，可以再现高度 血清中IgE达到高水平，在AD样病变中产生升高。 结果，例如可以筛选抑制KC诱导IL-18产生的抑制剂。
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公开(公告)号：US20090286734A1
公开(公告)日：2009-11-19
申请号：US12405844
申请日：2009-03-17
CPC分类号： A61K39/04 , A61K2039/53
摘要： The α antigen-encoding gene and the α antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of allergic diseases such as IgE production, histamine release and eosinophil infiltration, and therefore they are very effective for the prevention or treatment of atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis, and more broadly allergic diseases.
摘要翻译： α抗原编码基因和α抗原蛋白抑制白细胞介素-4等的产生，改善Th2型细胞因子显性状态，进一步抑制IgE产生，组胺释放和嗜酸性粒细胞浸润等过敏性疾病的各种病症， 因此它们对预防或治疗特应性皮炎，哮喘，过敏性鼻炎和过敏性结膜炎等特应性疾病以及更广泛的过敏性疾病非常有效。
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公开(公告)号：US07524675B2
公开(公告)日：2009-04-28
申请号：US11352342
申请日：2006-02-13
IPC分类号： C12N15/00 , A61K31/711 , C07H21/04
CPC分类号： A61K39/04 , A61K2039/53
摘要： The α antigen-encoding gene and the α antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of allergic diseases such as IgE production, histamine release and eosinophil infiltration, and therefore they are very effective for the prevention or treatment of atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis, and more broadly allergic diseases.
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公开(公告)号：US20090016079A1
公开(公告)日：2009-01-15
申请号：US11887009
申请日：2005-11-18
申请人： Hitoshi Mizutani
发明人： Hitoshi Mizutani
IPC分类号： F21V7/04
CPC分类号： G02B6/0073 , G02B6/0021 , G02B6/003 , G02F1/133524 , G02F1/133615 , H01L33/486 , H01L2924/0002 , H01L2924/00
摘要： A planar lighting apparatus is provided in which thinning is promoted while higher and more uniform brightness is achieved by maintaining an LED on a light-incoming face of a light guide plate easily and stably. A planar lighting apparatus 10 according to the present invention is provided with a light guide plate 2 and an LED 11 arranged on a light-incoming face 3 of the light guide plate 2. The light guide plate 2 has a pressing portion 5 formed integrally with the light guide plate 2 and opposite to the light-incoming face 3 with a predetermined gap d, and the LED 11 is held between the pressing portion 5 and the light-incoming face 3 and brought into pressure contact with the light-incoming face 3 by an elastic action of the pressing portion 5 so as to maintain the position and attitude with respect to the light guide plate 2 properly and stably.
摘要翻译： 提供了一种平面照明装置，其中通过在导光板的光入射面上容易且稳定地保持LED而实现更高和更均匀的亮度，促进了薄化。 根据本发明的平面照明装置10设置有导光板2和布置在导光板2的光入射面3上的LED11.导光板2具有与 导光板2并且具有预定间隙d与光入射面3相对，并且LED 11保持在按压部5和光入射面3之间并与光入射面3压力接触 通过按压部5的弹性作用，适当且稳定地保持相对于导光板2的位置和姿态。
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公开(公告)号：US07399171B2
公开(公告)日：2008-07-15
申请号：US11259059
申请日：2005-10-27
申请人： Takahiro Yamaguchi , Takashi Satou , Shigeki Torii , Toshiya Hayashi , Akihiro Yada , Hitoshi Mizutani , Takuya Fukitsuke , Kazunori Uchiyama , Naoki Hakamada
发明人： Takahiro Yamaguchi , Takashi Satou , Shigeki Torii , Toshiya Hayashi , Akihiro Yada , Hitoshi Mizutani , Takuya Fukitsuke , Kazunori Uchiyama , Naoki Hakamada
IPC分类号： F04C18/00
CPC分类号： B60T8/4031 , F04C2/086 , F04C2/102 , F04C15/06
摘要： The curvature of a circular arc constituted by a side of a suction groove is made larger than that of a circular arc constituted by a side of a discharge groove. Thus, when the suction groove and the discharge groove are viewed in the axial direction of a drive shaft, the distance between the suction groove and the discharge groove in the radial direction of a rotary portion is short in a region intersecting with a line W perpendicular to a centerline, and increases in accordance with a decrease in distance from containment portions. It is therefore possible to ensure a sufficient distance between the discharge and suction grooves and enhance a total fluid pressure generated therebetween, and the contact surface pressure that is necessitated by a second side plate to obtain a press-back force when being in contact with an outer rotor and an inner rotor is reduced.
摘要翻译： 由吸引槽的一侧构成的圆弧的曲率比由排出槽的一侧构成的圆弧的曲率大。 因此，当在驱动轴的轴向上观察吸入槽和排出槽时，旋转部的径向方向上的吸入槽和排出槽之间的距离在垂直于线W的区域中短 到中心线，并且随着距离容纳部分的距离的减小而增加。 因此，可以确保排出和吸入槽之间的足够的距离，并增强其间产生的总的流体压力，以及当与第二侧板接触时获得压靠力所需的接触表面压力 外转子和内转子减少。
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公开(公告)号：US20080133973A1
公开(公告)日：2008-06-05
申请号：US11851457
申请日：2007-09-07
申请人： Akihito MIZOE , Hitoshi MIZUTANI , Atsushi HIRATA
发明人： Akihito MIZOE , Hitoshi MIZUTANI , Atsushi HIRATA
IPC分类号： G06F11/34
CPC分类号： G06Q10/06 , G06F11/3476
摘要： The execution of a process is analyzed by a data processing method using a data analysis device for processing a job by combining the processes of transforming an input data and generating an output data. The execution history of the process is recorded, and each time the process is executed, it is determined whether the process execution is high in anomaly probability based on a determination indicator defined in advance. Upon determination that the process execution is high in anomaly probability, the process log information of the process including the determination indicator is recorded, and based on the process log information and the process execution history, the process high in anomaly probability is further analyzed, By determining whether the process to be analyzed is anomalous or not, the process history analysis information including the analysis result and the execution history of the process to be analyzed is generated.
摘要翻译： 通过使用用于处理作业的数据分析装置的数据处理方法来分析处理的执行，通过组合输入数据变换和产生输出数据的处理。 记录处理的执行历史，并且每次执行处理时，基于预先定义的确定指示，确定处理执行是否高于异常概率。 在确定过程执行异常概率高时，记录包括确定指示符的处理过程日志信息，并且基于过程日志信息和过程执行历史，进一步分析异常概率高的过程，通过 确定要分析的处理是否是异常的，生成包括分析结果和要分析的处理的执行历史的处理历史分析信息。
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7.发明申请Spread illuminating apparatus having light reflecting sheet with light diffusing portions 审中-公开具有光反射片的扩散照明装置具有光漫射部分公开(公告)号：US20070165419A1
公开(公告)日：2007-07-19
申请号：US10590112
申请日：2004-08-27
IPC分类号： F21V7/04
CPC分类号： G02B6/0031 , G02B6/0016
摘要： A spread illuminating apparatus is provided which includes: a light conductive plate having a light entrance surface and a light exit surface; a plurality of LEDs disposed at the light entrance surface of the light conductive plate; a light reflecting sheet disposed at the light exit surface so as to cover a portion of the light conductive plat located close to the side surface and also the LEDs, and a plurality of light diffusing portions disposed at the light reflecting sheet so as to cover respective LEDs. Lights leaking from the LEDs are diffused by the light diffusing portions thus preventing the brightness variation at the areas closed to the LEDs, and the leakage lights are reflected by the light reflecting sheet into the light conductive plate so as to be efficiently utilized thus achieving an enhanced brightness across the light exit surface of the light conductive plate.
摘要翻译： 提供了一种扩散照明装置，其包括：具有光入射表面和光出射表面的导光板; 设置在所述导光板的光入射面的多个LED; 设置在所述光出射面的光反射片，以覆盖位于靠近所述侧表面的所述导光板的一部分以及所述LED;以及多个光漫射部，其设置在所述光反射片上，以覆盖相应的 LED。 从LED泄漏的光被光扩散部分扩散，从而防止在LED闭合的区域处的亮度变化，并且漏光被光反射片反射到导光板中，从而实现了 在导光板的光出射表面上增强亮度。
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公开(公告)号：US20060219883A1
公开(公告)日：2006-10-05
申请号：US11373911
申请日：2006-03-14
申请人： Hitoshi Mizutani
发明人： Hitoshi Mizutani
IPC分类号： H01J5/02
CPC分类号： G02B6/003 , G02B6/0068 , H01L25/0753 , H01L33/54 , H01L2924/0002 , H01L2924/00
摘要： There is provided a spread illuminating apparatus including a light guide plate, and an LED structure which is disposed at a side surface of the light guide plate, includes: a substrate having electrode patterns formed thereon; an LED chip disposed on the electrode patterns; and a light-transmittable resin adapted to seal up the LED chip and exposed due to a lamp house not provided therearound, and which has a longitudinal dimension substantially equal to the longitudinal dimension of the side surface of the light guide plate. The electrode patterns are formed so as to cover substantially the entire area of a surface of the substrate. Accordingly, heat generated by the LED chip can be efficiently transmitted and released outside, and also light introduced in the light guide plate is suppressed from leaking out from the side surface of the light guide plate.
摘要翻译： 提供一种布置的照明装置，包括导光板和设置在导光板的侧面的LED结构，包括：具有形成在其上的电极图案的基板; 设置在电极图案上的LED芯片; 以及可透光树脂，其适于密封LED芯片并且由于未设置在其周围的灯室而暴露，并且其具有基本上等于导光板的侧表面的纵向尺寸的纵向尺寸。 电极图案形成为基本上覆盖基板表面的整个区域。 因此，能够将LED芯片产生的热量有效地向外部透射释放，并且抑制引入导光板的光从导光板的侧面泄漏出来。
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公开(公告)号：US4336696A
公开(公告)日：1982-06-29
申请号：US119155
申请日：1980-02-06
CPC分类号： F16D3/207 , Y10S464/904
摘要： A tripod type constant velocity universal joint for interconnecting two shafts to permit transmission of a driving force in a vehicle such as a motor car. In said tripod type constant velocity universal joint, a trunnion portion of the tripod shafts is urged against and supported by a tulip portion of a second shaft by a tripod spring, the spherical head of a mushroom-shaped member provided in the mounting hole of said trunnion portion is kept in contact with a recess in said tulip portion by the biasing force of a compression spring, and further, said mushroom-shaped member or said trunnion portion of the tripod shafts is formed to provide a spherically curved surface or a conical surface incorporating a straight line, in which the distance from the center of the joint is increased as a point on the external configuration leaves the center toward the outer periphery.
摘要翻译： 三脚架式等速万向接头，用于互连两个轴，以允许诸如汽车的车辆中的驱动力传递。 在所述三脚架式等速万向接头中，通过三脚架弹簧将三脚架轴的耳轴部分推压抵靠第二轴的郁金香部分，并设置在所述三脚架轴的安装孔中的伞形部件的球形头部 耳轴部分通过压缩弹簧的偏压力与所述郁金香部分中的凹部保持接触，此外，三角架轴的所述蘑菇形构件或所述耳轴部分形成为提供球形曲面或锥形表面 结合有直线，其中，距离接头中心的距离随着外部结构上的点离开外周而增加。
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公开(公告)号：US4278262A
公开(公告)日：1981-07-14
申请号：US70084
申请日：1979-08-27
CPC分类号： F16J3/041 , F16D3/845 , B29L2031/703
摘要： A boot for covering the juncture between a drive shaft and a universal joint casing formed of a resilient material and having a small end portion and a large end portion with a bellows structure therebetween. The bellows has undulations with ridges and valleys with ridge angles determined such that contact between adjacent undulations when the boot is operatively connected is confined to a plane. Preferably, the thickness of the resilient material is greater in a longitudinally center portion than in the remaining portions of the bellows and the distance between neighboring ridges in the central portion is greater than in the remaining portions.
摘要翻译： 一种用于覆盖驱动轴和由弹性材料形成的具有小端部和在其间具有波纹管结构的大端部的万向接头壳体之间的接合部的开口。 波纹管具有脊和谷的起伏，脊和谷的角度被确定为使得当靴子可操作地连接时相邻起伏之间的接触被限制在平面上。 优选地，弹性材料的厚度在纵向中心部分比在波纹管的其余部分中更大，并且中心部分中相邻脊之间的距离大于其余部分中的距离。
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