公开(公告)号：US20060011841A1

公开(公告)日：2006-01-19

申请号：US10890942

申请日：2004-07-14

Applicant: Kenneth Busch ,  Dennis Rabbe

Inventor： Kenneth Busch ,  Dennis Rabbe

IPC: G01N21/35

CPC classification number: G01N21/274 ,  G01J3/021 ,  G01J3/0232 ,  G01J3/28 ,  G01J2003/2866 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359

Abstract: The present invention is a dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials. The invention results from the novel combination of: 1) a low power He—Ne laser at right angles to the source beam of the spectrometer; 2) a folding mirror to redirect the collimated laser beam so that it is parallel to the source beam; 3) the tendency of diffraction gratings to produce overlapping spectra of higher orders; 4) a “polka dot” beam splitter to redirect the majority of the laser beam toward the reference detector; 5) PbS detectors and 6) a software routine written in Lab VIEW that automatically corrects the wavelength scale of the instrument from the positions of the 632.8 nm laser line in the spectrum.

公开(公告)号：US20050236563A1

公开(公告)日：2005-10-27

申请号：US11141773

申请日：2005-06-01

Applicant: Kenneth Busch ,  Dennis Rabbe

Inventor： Kenneth Busch ,  Dennis Rabbe

IPC: G01D18/00 ,  G01J3/28

CPC classification number: G01J3/28 ,  G01J3/0202 ,  G01J3/021 ,  G01J2003/2866

Abstract: The present invention is a dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials. The invention results from the novel combination of: 1) a low power He—Ne laser at right angles to the source beam of the spectrometer; 2) a folding mirror to redirect the collimated laser beam so that it is parallel to the source beam; 3) the tendency of diffraction gratings to produce overlapping spectra of higher orders; 4) a “polka dot” beam splitter to redirect the majority of the laser beam toward the reference detector; 5) PbS detectors and 6) a software routine written in Lab VIEW that automatically corrects the wavelength scale of the instrument from the positions of the 632.8 nm laser line in the spectrum.

Abstract translation: 本发明是一种分散衍射光栅，NIR光谱仪，可自动校准仪器的波长标度，无需外部波长校准材料。 本发明的结果是：1）与光谱仪的源光束成直角的低功率He-Ne激光器; 2）折叠镜，以使准直激光束重定向成平行于源光束; 3）衍射光栅产生高阶重叠光谱的趋势; 4）一个“波尔卡点”分束器，将大部分激光束重定向到参考探测器; 5）PbS检测器和6）Lab VIEW中编写的软件程序，可自动从波长632.8 nm激光线的位置校正仪器的波长范围。

公开(公告)号：US20050192767A1

公开(公告)日：2005-09-01

申请号：US11004597

申请日：2004-12-03

Applicant: Kenneth Busch ,  Isabel Maya Swamidoss ,  Sayo Fakayode ,  Marianna Busch

Inventor： Kenneth Busch ,  Isabel Maya Swamidoss ,  Sayo Fakayode ,  Marianna Busch

IPC: G01D18/00 ,  G01N21/33 ,  G01N21/64 ,  G01N21/65 ,  G01R33/46

CPC classification number: G01N21/33 ,  G01N21/64 ,  G01N21/65 ,  G01N2021/6417

Abstract: A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.

Abstract translation: 用于定量测定对映体纯度的新策略，其结合客体主体络合，光谱学和化学计量学建模。 对已知对映异构体组合物的样品的光谱数据进行一种称为偏最小二乘法（“PLS-1”）回归的多变量回归模型。 PLS-1回归产生一个数学模型，可用于预测未知对映体纯度的一组样品的对映异构体组成。