公开(公告)号：US5952187A

公开(公告)日：1999-09-14

申请号：US565143

申请日：1995-12-01

申请人： Kenneth J. Stenglein ,  Daniel B. Cawley ,  Bruce E. Maryanoff ,  Kirk L. Sorgi

发明人： Kenneth J. Stenglein ,  Daniel B. Cawley ,  Bruce E. Maryanoff ,  Kirk L. Sorgi

IPC分类号： G01N33/53 ,  C07H9/04 ,  C07H15/26 ,  C07K16/44 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/94 ,  G01N33/533 ,  C12N9/96 ,  G01N33/535

CPC分类号： C07H9/04 ,  G01N33/9473 ,  Y10S436/815

摘要： The present invention provides a topiramate immunoassay and reagents for use in the immunoassay. In particular, topiramate is derivatized at the sulfamate moiety or the 9-carbon or 10-carbon methyl group of topiramate to add a label bound directly or through a linking group for use as a tracer (competitive analyte analog) or to add a linking group bound to a carrier for use as an immunogen to induce anti-topiramate antibodies. Immunoassay methods and kits are also provided.

摘要翻译： 本发明提供托吡酯免疫测定法和用于免疫测定的试剂。 特别地，托吡酯衍生化在托吡酯的氨基磺酸酯部分或9-碳或10-碳甲基上，以添加直接或通过连接基团结合的标记，用作示踪剂（竞争性分析物类似物）或添加连接基团 结合载体用作免疫原诱导抗托吡酯抗体。 还提供免疫测定方法和试剂盒。

公开(公告)号：US5380825A

公开(公告)日：1995-01-10

申请号：US716309

申请日：1991-06-17

申请人： Kenneth J. Stenglein ,  Dennis M. Murray

发明人： Kenneth J. Stenglein ,  Dennis M. Murray

IPC分类号： C07H19/06 ,  C07K16/44 ,  G01N33/53 ,  C07K13/00 ,  C12N9/96 ,  G01N33/533 ,  G01N33/534

CPC分类号： C07H19/06 ,  C07K16/44 ,  G01N33/5308 ,  Y10S530/807

摘要： This invention relates to a method for the immunoassay of AZT (3'-azido-3'-deoxythymidine), also known as zidovudine, in biological fluids such as serum, semen, plasma and urine, as well as other body fluids. The invention also includes (1) various novel analogs of AZT useful in preparing immunogens for antibodies to AZT and in preparing labeled AZT, (2) immunogens for antibodies to AZT, (3) monoclonal and polyclonal antibodies to AZT, (4) labeled AZT analogs and (5) diagnostic test kits for the immunoassay.

摘要翻译： 本发明涉及在生物流体如血清，血浆和尿液以及其他体液中免疫测定AZT（3'-叠氮基-3'-脱氧胸苷）（也称齐多夫定）的方法。 本发明还包括（1）可用于制备AZT抗体免疫原和制备标记AZT的各种AZT类似物，（2）针对AZT抗体的免疫原，（3）AZT的单克隆抗体和多克隆抗体，（4）标记的AZT 类似物和（5）免疫测定的诊断试剂盒。

公开(公告)号：US5221611A

公开(公告)日：1993-06-22

申请号：US717614

申请日：1991-06-19

申请人： Kenneth J. Stenglein ,  Dennis M. Murray

发明人： Kenneth J. Stenglein ,  Dennis M. Murray

IPC分类号： C07K16/44 ,  C12P21/08 ,  G01N33/94

CPC分类号： G01N33/94 ,  C07K16/44 ,  Y10T436/143333

摘要： This invention relates to a method for the immunoassay of ddI (2',3'-dideoxyinosine), also known as didanosine, in biological fluids such as serum, semen, plasma and urine, as well as other body fluids. The invention also includes (1) various novel analogs of ddI useful in preparing immunogens for antibodies to ddI and in preparing labeled ddI, (2) immunogens for antibodies to ddI, (3) antibodies to ddI, (4) labeled ddI analogs and (5) diagnostic test kits for the immunoassay.

摘要翻译： 本发明涉及在生物流体如血清，血浆和尿液以及其他体液中免疫测定ddI（2'，3'-二脱氧肌苷）（也称为去羟肌苷）的方法。 本发明还包括（1）可用于制备ddI抗体的免疫原和制备标记的ddI的各种各样的ddI类似物，（2）用于ddI抗体的免疫原，（3）ddI抗体，（4）标记的ddI类似物和（ 5）免疫测定的诊断试剂盒。

公开(公告)号：US5051361A

公开(公告)日：1991-09-24

申请号：US259872

申请日：1988-10-19

申请人： Kenneth J. Stenglein ,  Dennis M. Murray

发明人： Kenneth J. Stenglein ,  Dennis M. Murray

IPC分类号： C07H19/06 ,  C07K16/44 ,  G01N33/53

CPC分类号： C07H19/06 ,  C07K16/44 ,  G01N33/5308 ,  Y10S530/807

摘要： This invention relates to a method for the immunoassay of AZT (3'-azido-3'-deoxythymidine), also known as zidovudine, in biological fluids such as serum, semen, plasma and urine, as well as other body fluids. The invention also includes (1) various novel analogs of AZT useful in preparing immunogens for antibodies to AZT and in preparing labeled AZT, (2) immunogens for antibodies to AZT, (3) monoclonal and polylonal antibodies to AZT, (4) labeled AZT analogs and (5) diagnostic test kits for the immunoassay.

摘要翻译： 本发明涉及在生物流体如血清，血浆和尿液以及其他体液中免疫测定AZT（3'-叠氮基-3'-脱氧胸苷）（也称齐多夫定）的方法。 本发明还包括（1）可用于制备AZT抗体免疫原和制备标记AZT的各种AZT类似物，（2）针对AZT抗体的免疫原，（3）AZT的单克隆抗体和多克隆抗体，（4）标记的AZT 类似物和（5）免疫测定的诊断试剂盒。