公开(公告)号：US5565467A

公开(公告)日：1996-10-15

申请号：US405120

申请日：1995-03-16

申请人： Kenneth W. Batchelor ,  Stephen V. Frye ,  George F. Dorsey, Jr. ,  Robert A. Mook, Jr.

发明人： Kenneth W. Batchelor ,  Stephen V. Frye ,  George F. Dorsey, Jr. ,  Robert A. Mook, Jr.

IPC分类号： A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00

CPC分类号： C07J3/005 ,  C07C235/82 ,  C07J41/0066 ,  C07J73/005 ,  C07C2103/14

摘要： The present invention relates to the compound of formula (I), ##STR1## also known as 17.beta.-N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5.alpha.-androst-1-en-3-one, solvates thereof, its preparation, intermediates used in its preparation, pharmaceutical formulations thereof and its use in the treatment of androgen responsive and mediated diseases.

摘要翻译： 本发明涉及式（I）化合物，也称为17β-N-（2,5-双（三氟甲基））苯基氨基甲酰基-4-氮杂-5α-雄甾-1-烯酸的化合物， en-3-酮，其溶剂合物，其制备，其制备中使用的中间体，其药物制剂及其在治疗雄激素反应性和介导性疾病中的用途。

公开(公告)号：US5846976A

公开(公告)日：1998-12-08

申请号：US708167

申请日：1996-08-22

申请人： Kenneth William Batchelor ,  Stephen Vernon Frye ,  George F. Dorsey, Jr. ,  Robert A. Mook, Jr.

发明人： Kenneth William Batchelor ,  Stephen Vernon Frye ,  George F. Dorsey, Jr. ,  Robert A. Mook, Jr.

IPC分类号： A61K31/58 ,  A61K31/56 ,  A61P43/00 ,  C07C235/82 ,  C07J3/00 ,  C07J41/00 ,  C07J73/00

CPC分类号： C07J3/005 ,  C07C235/82 ,  C07J41/0066 ,  C07J73/005 ,  C07C2103/14

摘要： The present invention relates to the compound of formula (I), ##STR1## also known as 17.beta.-N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5.alpha.-androst-1-en-3-one, solvates thereof, its preparation, intermediates used in its preparation, pharmaceutical formulations thereof and its use in the treatment of androgen responsive and mediated diseases.