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公开(公告)号：US5209919A
公开(公告)日：1993-05-11
申请号：US693248
申请日：1991-04-26
申请人： Kenneth W. Turteltaub , John S. Vogel , James S. Felton , Barton L. Gledhill , Jay C. Davis , Larry H. Stanker
发明人： Kenneth W. Turteltaub , John S. Vogel , James S. Felton , Barton L. Gledhill , Jay C. Davis , Larry H. Stanker
CPC分类号： G01N33/60 , A61K51/0423 , A61K51/0459 , A61K2123/00 , Y10T436/13
摘要： Disclosed is a method of quantifying molecules in biological substances, comprising:a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere,b. preparing a long-lived radioisotope labeled reactive chemical specie,c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof,d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host,e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources,f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and,g. measuring the radioisotope concentration in said material by means of direct isotopic counting.
摘要翻译： 公开了一种量化生物物质中的分子的方法，包括：a。 选择其中存在放射性同位素的生物宿主的浓度等于或小于环境生物圈中的浓度，b。 制备长寿命放射性同位素标记的反应性化学物质，c。 以足够低的剂量将所述化学物质施用于所述生物宿主，以避免对其生物系统的显着明显的损害，d。 允许一段时间足以在所述宿主的所有生物系统中传播所述化学物质与所述宿主的相互作用，例如， 从足够的方式从所述宿主中分离出生物物质的反应级分，以避免所述物质从外界来源污染，f。 通过合适的方式将生物物质的所述部分转化为在几种可能的离子源中的至少一种中有效地产生带电离子的材料，而不引入显着的同位素分馏，以及g。 通过直接同位素计数测量所述材料中的放射性同位素浓度。
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2.发明授权Method for detection of long-lived radioisotopes in small biochemical samples 失效小生化样品中长寿命放射性同位素检测方法
公开(公告)号：US5366721A
公开(公告)日：1994-11-22
申请号：US699385
申请日：1991-04-26
CPC分类号： G01N33/60 , A61K51/0423 , A61K51/0459 , A61K2123/00 , Y10T436/13
摘要： Disclosed is a method for detection of long-lived radioisotopes in small bio-chemical samples, comprising:a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere,b. preparing a long-lived radioisotope labeled reactive chemical specie,c. administering said chemical specie to said biologist host in doses sufficiently low to avoid significant overt damage to the biological system thereof,d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host,e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources,f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and,g. measuring the radioisotope concentration in said material by means of direct isotopic counting.
摘要翻译： 公开了一种在小型生物化学样品中检测长寿命放射性同位素的方法，包括：a。 选择其中存在放射性同位素的生物宿主的浓度等于或小于环境生物圈中的浓度，b。 制备长寿命放射性同位素标记的反应性化学物质，c。 以足够低的剂量将所述化学物质给予所述生物学家宿主，以避免对其生物系统的显着明显的损害，d。 允许一段时间足以在所述宿主的所有生物系统中传播所述化学物质与所述宿主的相互作用，例如， 从足够的方式从所述宿主中分离出生物物质的反应级分，以避免所述物质从外界来源污染，f。 通过合适的方式将生物物质的所述部分转化为在几种可能的离子源中的至少一种中有效地产生带电离子的材料，而不引入显着的同位素分馏，以及g。 通过直接同位素计数测量所述材料中的放射性同位素浓度。
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公开(公告)号：US5376355A
公开(公告)日：1994-12-27
申请号：US693239
申请日：1991-04-26
CPC分类号： G01N33/60 , A61K51/0423 , A61K51/0459 , A61K2123/00 , Y10T436/13
摘要： Disclosed is a method of quantifying molecules in biological substances comprising:a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere,b. preparing a long-lived radioisotope labeled reactive chemical specie,c. administering said chemical specie to said biological host in doses sufficiently low to avoid significant overt damage to the biological system thereof,d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host,e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources,f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and,g. measuring the radioisotope concentration in said material by means of direct isotopic counting.
摘要翻译： 公开了一种量化生物物质中的分子的方法，包括：a。 选择其中存在放射性同位素的生物宿主的浓度等于或小于环境生物圈中的浓度，b。 制备长寿命放射性同位素标记的反应性化学物质，c。 以足够低的剂量将所述化学物质施用于所述生物宿主，以避免对其生物系统的显着明显的损害，d。 允许一段时间足以在所述宿主的所有生物系统中传播所述化学物质与所述宿主的相互作用，例如， 从足够的方式从所述宿主中分离出生物物质的反应级分，以避免所述物质从外界来源污染，f。 通过合适的方式将生物物质的所述部分转化为在几种可能的离子源中的至少一种中有效地产生带电离子的材料，而不引入显着的同位素分馏，以及g。 通过直接同位素计数测量所述材料中的放射性同位素浓度。
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