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公开(公告)号：US20090142336A1
公开(公告)日：2009-06-04
申请号：US12280961
申请日：2007-02-23
申请人： Kenneth Walsh , Noriyuki Ouchi , Ling Zeng
发明人： Kenneth Walsh , Noriyuki Ouchi , Ling Zeng
IPC分类号： A61K39/395 , A61K31/7088 , A61K31/7105 , A61K38/02
CPC分类号： A61K38/2221 , A61K38/1709 , A61K38/1825 , A61K38/39 , A61K38/45 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The present invention relates to metabolic regulators that affect metabolic function, for example metabolic regulators that affect muscle mass, muscle regeneration, muscle hypertrophy, fat mass, insulin and glucose sensitivity, angiogenesis and cardiovascular function. In particular, the present invention relates to modulating metabolic function by administering an effective amount of a pharmaceutical composition comprising an agent, where the agent activates or inhibits the activity and/or gene expression of the metabolic regulator. The metabolic regulators of the present invention are, for example MSP1 (2160028F08Rik; SEQ ID NO: 16); MSP2 (2310043I08Rik; SEQ ID NO: 17); MSP3 (NM_026754;1 110017116Rik; SEQ ID NO: 1); MSP4 (4732466D17Rik; SEQ BD NO: 18); MSP 5 (NM_024237; 1600015H20Rik; SEQ ID NO: 12); Ins16 (AF_156094; SEQ ID NO: 20). The present invention also provides methods to screen for agents that affect the metabolic regulators of the present invention.
摘要翻译： 本发明涉及影响代谢功能的代谢调节剂，例如影响肌肉质量的代谢调节剂，肌肉再生，肌肉肥大，脂肪量，胰岛素和葡萄糖敏感性，血管生成和心血管功能。 特别地，本发明涉及通过施用有效量的包含试剂的药物组合物调节代谢功能，其中所述试剂活化或抑制代谢调节剂的活性和/或基因表达。 本发明的代谢调节剂是例如MSP1（2160028F08Rik; SEQ ID NO：16）; MSP2（2310043I08Rik; SEQ ID NO：17）; MSP3（NM_026754; 110017116Rik; SEQ ID NO：1）; MSP4（4732466D17Rik; SEQ ID NO：18）; MSP 5（NM_024237; 1600015H20Rik; SEQ ID NO：12）; Ins16（AF_156094; SEQ ID NO：20）。 本发明还提供筛选影响本发明的代谢调节剂的试剂的方法。
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公开(公告)号：US20210189134A1
公开(公告)日：2021-06-24
申请号：US16819011
申请日：2020-03-13
申请人： Jiabing Dai , Ling Zeng , Weihu Li , Huayong Yang
发明人： Jiabing Dai , Ling Zeng , Weihu Li , Huayong Yang
摘要： The invention disclosures a wood composite board and a preparation method thereof, comprising: mixing wood materials with the adhesive evenly, paving the mixed wood materials on the boards, and then forming through high-temperature and hot-pressing, the wood composite board of the invention has good evenness, high surface bonding strength, low moisture content, good dimensional stability, anti-cracking and anti-thermocycling performance, can use compound adhesives such as polyurethane adhesive, formaldehyde-free biomass adhesive or formaldehyde-type adhesives, waterproofing agent, mildew preventive, etc., and by the invention, fiber finish coat with different environmental protection standards can be produced according to market requirements, and the fiber finish coat has a low thickness swelling rate of water absorption and a thickness of 0.5-3 mm.
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