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    Systems and methods for delivering agents into targeted tissue of a living being
    1.
    发明申请
    Systems and methods for delivering agents into targeted tissue of a living being 有权

    公开(公告)号：US20040158227A1

    公开(公告)日：2004-08-12

    申请号：US10763558

    申请日：2004-01-23

    申请人： Kensey Nash Corporation, Marsh Creek Corporate Center

    发明人： John E. Nash ,  Douglas G. Evans ,  David M. Hoganson

    IPC分类号： A61M031/00

    CPC分类号： A61B17/32037 ,  A61B17/320758 ,  A61B17/3478 ,  A61B18/14 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22038 ,  A61B2018/00208 ,  A61B2018/00291 ,  A61B2018/00392 ,  A61B2018/00839 ,  A61B2018/1861 ,  A61B2018/2005

    摘要： The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations in the into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal. When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surroundings tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.

    Transmyocardial revascularization system and method of use
    2.
    发明申请
    Transmyocardial revascularization system and method of use 失效

    公开(公告)号：US20030073973A1

    公开(公告)日：2003-04-17

    申请号：US10301007

    申请日：2002-11-21

    申请人： Kensey Nash Corporation

    发明人： Douglas G. Evans ,  John E. Nash

    IPC分类号： A61B017/34

    CPC分类号： A61F2/82 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61F2/2493

    摘要： A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardium and deployment instruments and associated components for deploying the inserts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or non-resorbable. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enable blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used. The deployment instruments may make use of a stabilizing device to stabilize them during the procedure of inserting the inserts into the myocardium. A controller may also be provided as part of the system to coordinate the operation of the deployment instrument with the cardiac cycle. The formation of the lumens can be achieved either by the inserts or by some other means, such as a piercing tip or an energy applicator forming a portion of the instrument. The inserts may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.

    Transmyocardial revascularization system and method of use
    5.
    发明申请
    Transmyocardial revascularization system and method of use 有权
    心肌血运重建系统及其使用方法

    公开(公告)号：US20010008969A1

    公开(公告)日：2001-07-19

    申请号：US09773855

    申请日：2001-02-01

    申请人： Kensey Nash Corporation

    发明人： Douglas G. Evans ,  John E. Nash

    IPC分类号： A61B017/34

    CPC分类号： A61F2/82 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61F2/2493

    摘要： A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardium and deployment instruments and associated components for deploying the inserts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or non-resorbable. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enable blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used. The deployment instruments may make use of a stabilizing device to stabilize them during the procedure of inserting the inserts into the myocardium. A controller may also be provided as part of the system to coordinate the operation of the deployment instrument with the cardiac cycle. The formation of the lumens can be achieved either by the inserts or by some other means, such as a piercing tip or an energy applicator forming a portion of the instrument. The inserts may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.

    摘要翻译： 一种经心肌血运重建系统，其包括由材料组成的多个插入物，以在心肌的组织中引发愈合反应，以及用于将插入物部署到心肌壁上的相关组件。 插入件布置成设置在心肌壁中相应的腔或通道内。 插入件可以采取各种形式，例如是实心构件，管状构件或多孔构件，并且可以是可再吸收的，部分可再吸收的或不可再吸收的。 在一些实施例中，插入物被布置成在心肌壁中的通道内留在适当的位置，以产生多个流明，使得血液能够流过并流入相邻的毛细血管。 根据所使用的特定部署仪器，这些展开装置被设置成从心内膜或心外膜刺穿心肌的组织以将插入物插入心肌。 在将插入物插入心肌的过程中，展开装置可以利用稳定装置来稳定它们。 还可以提供控制器作为系统的一部分，以协调部署仪器与心动周期的操作。 腔的形成可以通过插入件或通过其它手段实现，例如刺穿尖端或形成器械的一部分的能量施加器。 插入物可以包括一种或多种药物，生物活性剂，不透射线材料等。