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公开(公告)号：US08703178B2
公开(公告)日：2014-04-22
申请号：US12528194
申请日：2008-03-06
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译： 本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。 本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。
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公开(公告)号：US20100122927A1
公开(公告)日：2010-05-20
申请号：US12618931
申请日：2009-11-16
IPC分类号： B65D83/00
CPC分类号： B65D75/366 , B65D2215/00
摘要： Provision of a blister package that cannot be opened easily by infants, but can be opened easily, certainly and safely by a user when in use. A blister package 100 containing a blister 1 and a cover sheet 2, wherein the blister has a groove 3 formed in an outer edge section 1A thereof where the cover sheet is adhered and the groove 3 is free of adhesion of the sheet. The cover sheet is adhered to the outermost circumference 1a of the outer edge section 1A, the groove 3 is formed on the inward side of the outermost circumference 1a, and the cover sheet is not adhered to the area on the inward side of the groove 3.
摘要翻译： 提供婴儿不能轻松打开的泡罩包装，但使用时可以方便，安全地打开。 包含泡罩1和覆盖片2的泡罩包装100，其中泡罩具有形成在其外缘部分1A中的覆盖片粘附的槽3，并且槽3没有片材的粘附。 覆盖片附着在外缘部1A的最外周1a上，槽3形成在最外周1a的内侧，覆盖片不粘附在槽3的内侧的区域 。
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公开(公告)号：US09808609B2
公开(公告)日：2017-11-07
申请号：US13983510
申请日：2012-02-01
IPC分类号： A61M35/00 , A61L31/12 , A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61M35/00 , A61K9/7053 , A61K31/405 , A61K31/663 , A61L31/129
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 500,000-1,600,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
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公开(公告)号：US08251213B2
公开(公告)日：2012-08-28
申请号：US12167085
申请日：2008-07-02
IPC分类号： A61B17/06
CPC分类号： A61F15/001 , A61F13/551 , A61F2013/00165 , A61F2013/00365 , Y10T428/13
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
摘要翻译： 贴片包装结构技术领域本发明涉及一种贴片包装结构，其包括：包括第一片材和第二片材的封装，所述第一片材和第二片材在其周边部分被密封在一起; 以及布置在所述包装中的贴片，所述贴片包含背衬，层压在所述背衬的至少一侧上的压敏粘合剂层以及保护所述压敏粘合剂层的压敏粘合剂表面的剥离衬垫， 所述剥离衬垫在其表面上具有在使用所述贴片时支撑所述剥离衬垫剥离的切割线，所述贴片设置在所述包装中，使得所述剥离衬垫面向所述第一片材的内表面， 所述第一片材具有第一区域，其中所述第一片材的内表面面向所述剥离衬垫的切割线，所述第一片材在所述第一区域中具有所述第一片材的内表面与所述第一片材的内表面之间的最小第一距离， 释放衬垫的表面，并且第一片材的内表面在第一区域中以最小第一距离与释放衬垫的表面间隔开。
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公开(公告)号：US08146741B2
公开(公告)日：2012-04-03
申请号：US12618931
申请日：2009-11-16
IPC分类号： A61B17/06
CPC分类号： B65D75/366 , B65D2215/00
摘要： A blister package comprises a blister and a cover sheet, and the blister has a groove formed in an outer edge section of the blister. The outer edge section of the blister includes an outer region and an inner region, the groove is formed on the inward side of the outer region, and the inner region is formed on the inward side of the groove. The peel strength between the outer region and the cover sheet is greater than the tear strength of the cover sheet, and the peel strength between the inner region and cover sheet is smaller than the tear strength of the cover sheet.
摘要翻译： 泡罩包装件包括泡罩和盖片，并且泡罩具有形成在泡罩的外边缘部分中的凹槽。 泡罩的外缘部分包括外部区域和内部区域，凹槽形成在外部区域的内侧，并且内部区域形成在凹槽的内侧。 外部区域和覆盖片之间的剥离强度大于覆盖片的撕裂强度，并且内部区域和覆盖片材之间的剥离强度小于覆盖片材的撕裂强度。
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公开(公告)号：US08141706B2
公开(公告)日：2012-03-27
申请号：US12167085
申请日：2008-07-02
IPC分类号： A61B17/06
摘要： The present invention relates to a patch package structure which includes: a package including a first sheet material and a second sheet material, the first and second sheet materials being sealed together in peripheral parts thereof; and a patch disposed in the package, the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer, the release liner having on a surface thereof a cut line supporting a peel-off of the release liner at the time of using the patch, the patch being disposed in the package so that the release liner faces the inner surface of the first sheet material, the first sheet material having a first region in which the inner surface of the first sheet material faces the cut line of the release liner, the first sheet material having in the first region a minimum first distance between the inner surface of the first sheet material and the surface of the release liner, and the inner surface of the first sheet material being spaced from the surface of the release liner at the minimum first distance in the first region.
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公开(公告)号：US20100098747A1
公开(公告)日：2010-04-22
申请号：US12528194
申请日：2008-03-06
IPC分类号： A61K9/70 , A61K31/138 , A61P9/00
CPC分类号： A61K31/138 , A61K9/7053 , A61K9/7061
摘要： The present invention relates to a percutaneous administration device of bisoprolol, which includes a backing; and a pressure-sensitive adhesive layer containing bisoprolol, which is laminated on one surface of the backing, wherein the maximum value of a release rate of bisoprolol during a period of from immediately after the application on skin until a lapse of 24 hours is 30 μg/cm2/hr or less; and wherein the release rate of bisoprolol at the time of a lapse of 24 hours after the application on skin is 10 μg/cm2/hr or less. The percutaneous administration device of the present invention is reduced in the skin irritation during the application, especially at the time of peeling, and is capable of persistently administrating a therapeutically or preventively effective amount of bisoprolol into a living body.
摘要翻译： 本发明涉及比索洛尔的经皮给药装置，其包括背衬; 以及层压在背衬的一个表面上的含有比索洛尔的压敏粘合剂层，其中在施用于皮肤上直到24小时之后的期间，比索洛尔的释放速率的最大值为30μg / cm 2 / hr以下; 并且其中在皮肤上施用后24小时时比索洛尔的释放速率为10μg/ cm 2 / hr以下。 本发明的经皮给药装置，特别是剥离时，皮肤刺激性降低，能够将治疗或预防有效量的比索洛尔施用于生物体。
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公开(公告)号：US09433533B2
公开(公告)日：2016-09-06
申请号：US11972910
申请日：2008-01-11
CPC分类号： A61F13/0203 , A61F13/551 , A61F15/001
摘要： The present invention provides a patch package structure, which includes: a package including a first sheet material which is planar and a second sheet material which has been molded, the first and second sheet materials being sealed together in peripheral parts thereof, and a patch disposed in the package, in which the patch contains a backing, a pressure-sensitive adhesive layer laminated on at least one side of the backing, and a release liner which protects a pressure-sensitive adhesive surface of the pressure-sensitive adhesive layer; the second sheet material has been molded so as to have a protrudent part in at least a substantially central area thereof, the protrudent part having a planar outer shape larger than a planar outer shape of the release liner and having at least one recessed part; d is not smaller than T, in which d is the minimum gap distance between the inner surface of the first sheet material and the inner surface of the second sheet material at the recessed part and T is a thickness of the patch; and, at the boundary between the sealed part where the first and second sheet materials are sealed together and an unsealed part, the outer surface of the second sheet material rises at an obtuse angle.
摘要翻译： 本发明提供了一种贴片包装结构，其包括：包括平面的第一片材和已经模制的第二片材的封装，第一和第二片材在其周边部分被密封在一起，并且贴片布置 在其中贴片包含背衬的包装中，层压在背衬的至少一侧上的压敏粘合剂层和保护压敏粘合剂层的压敏粘合剂表面的剥离衬垫; 第二片材已经被模制成在其至少大致中心区域具有突出部分，突出部分具有比剥离衬垫的平面外形大的平面外形，并且具有至少一个凹部; d不小于T，其中d是第一片材的内表面和凹陷部分的第二片材的内表面之间的最小间隙距离，T是贴片的厚度; 并且在第一和第二片材密封在一起的密封部分与未密封部分之间的边界处，第二片材的外表面以钝角上升。
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公开(公告)号：US09351942B2
公开(公告)日：2016-05-31
申请号：US13983481
申请日：2012-02-01
IPC分类号： A61K9/70 , A61K31/405 , A61K31/663
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译： 本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。 该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁 硅酸铝 在贴片制剂中，上述粘合剂层还含有药物。
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公开(公告)号：US20130315978A1
公开(公告)日：2013-11-28
申请号：US13983481
申请日：2012-02-01
IPC分类号： A61K9/70 , A61K31/663 , A61K31/405
CPC分类号： A61K9/7053 , A61K31/405 , A61K31/663 , Y10T428/2857
摘要： The invention provides a patch and a patch preparation having an adhesive layer with a high adhesive force, wherein the hydrophobic adhesive layer does not bloom even when an organic fluid component having high polarity is contained therein. The patch contains a support and an adhesive layer on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber having a viscosity average molecular weight of 1,700,000-6,500,000, an organic fluid component having high polarity, a tackifier, and magnesium aluminometasilicate. In the patch preparation, the above-mentioned adhesive layer further contains a drug.
摘要翻译： 本发明提供了具有粘合力高的贴剂和贴片制剂，其中即使含有高极性的有机流体组分，疏水性粘合剂层也不会起泡。 该贴片在支撑体的至少一个表面上包含支撑体和粘合剂层，其中粘合剂层含有粘均分子量为170万至6,500,000的合成橡胶，具有高极性的有机流体组分，增粘剂和镁 硅酸铝 在贴片制剂中，上述粘合剂层还含有药物。
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