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公开(公告)号：US4968606A
公开(公告)日：1990-11-06
申请号：US407697
申请日：1989-09-15
申请人： Kenzo Yokozeki , Hideyuki Shirae , Koji Kubota
发明人： Kenzo Yokozeki , Hideyuki Shirae , Koji Kubota
IPC分类号： C12P19/02 , C07H19/056 , C12P19/28 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/185 , C12R1/365 , C12R1/38 , C12R1/425 , C12R1/465 , C12R1/63 , C12R1/64
CPC分类号： C12P19/28 , Y10S435/847 , Y10S435/852
摘要： The present invention relates to methods for producing ribavirin utilizing microorganisms and a method for producing ribose-1-phosphoric acid which is a precursor of ribavirin. The methods involve contacting certain microorganisms with orotidine, orotidic acid, or salts thereof, and inorganic phosphoric acid or a salt thereof (to produce ribose-1-phosphoric acid), and further with 1,2,4-triazole-3-carboxamide or a salt thereof (to produce ribavirin) in an aqueous solvent.
摘要翻译： 本发明涉及利用微生物生产利巴韦林的方法以及作为利巴韦林前体的核糖-1-磷酸的制备方法。 所述方法包括将某些微生物与乳清酸，orotidic酸或其盐，和无机磷酸或其盐（产生核糖-1-磷酸），以及进一步与1,2,4-三唑-3-甲酰胺或 其盐（以产生利巴韦林）在水性溶剂中。
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公开(公告)号：US4962193A
公开(公告)日：1990-10-09
申请号：US291155
申请日：1988-12-28
申请人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
发明人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
CPC分类号： C12P19/02 , C12P19/38 , Y10S435/822
摘要： A biological process for producing a 2',3'-dideoxynucleoside from 2',3'-dideoxyuridine is disclosed. the 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.
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3.发明授权Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides 失效2'，3'-二脱氧核苷的生产和纯化方法，以及产生2'，3'-二脱氧-2'，3'-二脱氢核苷的方法
公开(公告)号：US4835104A
公开(公告)日：1989-05-30
申请号：US191370
申请日：1988-05-09
申请人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
发明人： Kenzo Yokozeki , Hideyuki Shirae , Hiroshi Shiragami , Yasuo Irie , Naohiko Yasuda , Masaru Otani , Toshiya Tanabe
CPC分类号： C12P19/02 , C12P19/38 , Y10S435/822
摘要： A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.
摘要翻译： 公开了一种从2'，3'-二脱氧尿苷生产2'，3'-二脱氧核苷的生物工艺。 可以使用多孔非极性树脂吸附剂容易地纯化2'，3'-二脱氧核苷。
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公开(公告)号：US4970148A
公开(公告)日：1990-11-13
申请号：US254584
申请日：1988-10-07
IPC分类号： C12P17/18 , C12P19/40 , C12R1/01 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/18 , C12R1/19 , C12R1/20 , C12R1/22 , C12R1/265 , C12R1/32 , C12R1/365 , C12R1/37 , C12R1/38 , C12R1/41 , C12R1/42 , C12R1/425 , C12R1/45 , C12R1/465 , C12R1/63 , C12R1/64
CPC分类号： C12P19/40 , Y10S435/822
摘要： A method of producing dideoxyinosine involving contacting as a substrate 2',3'-dideoxyadenosine with a microorganism which is capable of converting the substrate into 2',3'-dideoxyinosine.
摘要翻译： 涉及将能够将底物转化为2'，3'-二脱氧肌苷的微生物作为底物2'，3'-双脱氧腺苷接触基质的双脱氧肌苷的方法。
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