公开(公告)号：US07104958B2

公开(公告)日：2006-09-12

申请号：US10442194

申请日：2003-05-21

申请人： Kevin Crutchfield ,  B. Robert Mozayeni ,  John B. Davidson ,  Simon Fitall ,  Rakesh Lall

发明人： Kevin Crutchfield ,  B. Robert Mozayeni ,  John B. Davidson ,  Simon Fitall ,  Rakesh Lall

IPC分类号： A61B8/02

CPC分类号： A61B5/02007 ,  A61B5/0002 ,  A61B5/031 ,  A61B5/4088 ,  A61B5/411 ,  A61B5/7275 ,  A61B8/06 ,  A61B8/0808 ,  A61B8/56 ,  G01S15/8979 ,  G06F19/00

摘要： The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.

摘要翻译： 本发明涉及用于评估单个或多个血管和节段中的血流的系统和方法，用于评估血管健康，进行临床试验，筛选治疗干预效果，评估风险因素，评估颅内压和分析结果 以定义的方式。 本发明能够直接监测血管，特别是脑血管系统的治疗，物质和装置。 相关血流参数包括平均流速，收缩期加速度和搏动指数。 这些参数的测量和分析以及其他参数提供了有关个体和多个血管的血管健康状况的细节，以及对个体血管总体健康状况的全面分析。 本发明可以跟踪经历颅内压增加的个体的发作，进展和治疗功效，或者可以帮助将血管系统的潜在的脆弱性识别为与肝硬化或痴呆相关并表现为正常压力的正常压力。