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公开(公告)号:US20070065401A1
公开(公告)日:2007-03-22
申请号:US11548422
申请日:2006-10-11
IPC分类号: A61K38/20
CPC分类号: A61K47/60 , A61K38/20 , A61K38/21 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.