公开(公告)号：US20110014624A1

公开(公告)日：2011-01-20

申请号：US12921717

申请日：2009-03-12

申请人： Kevin Michael McCarthy ,  Megan Jill Hone ,  Robin Allison Heller-Harrison ,  Mark William Leonard

发明人： Kevin Michael McCarthy ,  Megan Jill Hone ,  Robin Allison Heller-Harrison ,  Mark William Leonard

IPC分类号： C12Q1/68 ,  C12N5/071

CPC分类号： C12N15/85 ,  C07K16/00 ,  C07K16/2803 ,  C12N2830/42 ,  C12N2840/203

摘要： The present invention provides methods of identifying a clonal population of cells suitable for large-scale production of a protein of interest. The invention further provides methods for high-throughput screening for genetic rearrangements in the gene encoding the protein of interest, whereby the absence of a deletion in the gene encoding the protein of interest indicates that the cell is suitable for large-scale production of the protein of interest.

摘要翻译： 本发明提供了鉴定适合于大规模生产目的蛋白质的细胞的克隆群体的方法。 本发明还提供了用于在编码目的蛋白质的基因中进行遗传重排的高通量筛选的方法，由此在编码目的蛋白质的基因中缺失缺失表明该细胞适合于大规模生产蛋白质 出于兴趣。

公开(公告)号：US07430535B2

公开(公告)日：2008-09-30

申请号：US10125034

申请日：2002-04-18

申请人： Karen Ann Dougherty ,  AnneMarie Jonason ,  Kevin Michael McCarthy ,  Jannic Georges Cheyns

发明人： Karen Ann Dougherty ,  AnneMarie Jonason ,  Kevin Michael McCarthy ,  Jannic Georges Cheyns

IPC分类号： G06Q40/00 ,  G06F17/30 ,  G06F15/173

CPC分类号： G06Q30/02 ,  G06Q40/025 ,  G06Q50/188

摘要： A system including at least one computer configured as a server that contains a database of deal information, business rules, libraries and templates for deals for at least one business entity is provided. The system further includes at least one client system connected to the server through a network. The server is configured to prompt a user to create a deal, including identifying deal team members, notify members of the deal team of tasks to perform and milestones accomplished, receive documents relating to a deal from a client system that are submitted for approval by a user, and provide access to the deal documents through a client system for review and approval.

摘要翻译： 提供了一种包括配置为服务器的至少一个计算机的系统，其包含用于至少一个业务实体的交易的交易信息，业务规则，库和模板的数据库。 该系统还包括通过网络连接到服务器的至少一个客户端系统。 服务器被配置为提示用户创建交易，包括识别交易团队成员，通知交易团队的成员执行任务和完成的里程碑，从客户端系统接收与交易提交的批准文件 用户，并通过客户系统提供交易文件的访问以供审核和批准。