METHODS AND COMPOSITIONS FOR JOINT HEALING AND REPAIR
    1.
    发明申请
    METHODS AND COMPOSITIONS FOR JOINT HEALING AND REPAIR 审中-公开
    联合治疗和修复的方法和组合

    公开(公告)号:US20110245929A1

    公开(公告)日:2011-10-06

    申请号:US13042295

    申请日:2011-03-07

    IPC分类号: A61F2/02 A61B17/04 A61B17/32

    摘要: The invention in some aspects provides implantable articles comprising in vitro-prepared tissues for joint repair. Devices and methods for introducing implantable articles into a subject are also provided. In some aspects of the invention devices and systems for minimally invasive surgery are provided. In some aspects, methods are provided for regenerating a bone-tendon interface in a subject by implanting an in vitro-prepared tissue between a detached tendon or detached ligament and a bone in a subject. In other aspects, methods are provided for maintaining exogenous, viable fibroblasts between a detached tendon and a bone in a subject. In other aspects, methods are provided for delivering exogenous cytokines and/or growth factors to a damaged bone-tendon interface.

    摘要翻译: 本发明在一些方面提供了包含用于关节修复的体外制备的组织的可植入制品。 还提供了用于将可植入物品引入被检体的装置和方法。 在本发明的一些方面,提供了用于微创手术的装置和系统。 在一些方面,提供了通过在受试者的分离的肌腱或分离的韧带和骨之间植入体外制备的组织来提供用于在受试者中再生骨 - 肌腱界面的方法。 在其它方面,提供了用于在受试者的分离的肌腱和骨之间维持外源的,活的成纤维细胞的方法。 在其他方面,提供了用于将外源性细胞因子和/或生长因子递送至损伤的骨 - 肌腱界面的方法。