公开(公告)号：US07749519B2

公开(公告)日：2010-07-06

申请号：US11637567

申请日：2006-12-11

申请人： Kim Lee Sim ,  Stephen Hoffman ,  Myriam Arevalo ,  Socrates Herrera

发明人： Kim Lee Sim ,  Stephen Hoffman ,  Myriam Arevalo ,  Socrates Herrera

IPC分类号： A61K39/00 ,  A61K39/38 ,  A01N43/04 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/445 ,  A61K39/00 ,  A61K39/015 ,  A61K2039/55566 ,  Y02A50/412

摘要： Malaria in humans is caused by infection with Plasmodium species parasites including P. vivax. The biology and immunobilogy of P. vivax is distinct from that of P. falciparum. Provided are unique synthetic polypeptides and DNA molecules which encode them. Each of these molecules correspond to regions of the circumsporozoite protein of P. vivax. Each molecule comprises sequences corresponding to several repeats of the central region of the Pv 210 variant fused to sequences corresponding to several repeats of the central region of the Pv 247 variant. Each molecule additionally comprises sequences corresponding to either the amino terminus, the carboxy terminus, or both the amino and carboxy termini of the PvCSP. Also provided are vaccines comprising these unique sequences and methods of using these vaccines and sequences to prevent and treat Pv malaria.

摘要翻译： 人类的疟疾是由包括间日疟原虫在内的疟原虫寄生虫感染引起的。 间日疟原虫的生物学和免疫学不同于恶性疟原虫的生物学和免疫学。 提供了编码它们的独特的合成多肽和DNA分子。 这些分子中的每一个对应于间日疟原虫的环子孢子蛋白的区域。 每个分子包含对应于Pv 210变体的中心区域的几个重复序列的序列，其与对应于Pv 247变体的中心区域的几个重复序列融合。 每个分子另外包含对应于PvCSP的氨基末端，羧基末端或氨基和羧基末端的序列。 还提供了包含这些独特序列的疫苗和使用这些疫苗和序列来预防和治疗Pv疟疾的疫苗。

公开(公告)号：US20080057085A1

公开(公告)日：2008-03-06

申请号：US11637567

申请日：2006-12-11

申请人： Kim Sim ,  Stephen Hoffman ,  Myriam Arevalo ,  Socrates Herrera

发明人： Kim Sim ,  Stephen Hoffman ,  Myriam Arevalo ,  Socrates Herrera

IPC分类号： A61K39/015 ,  C07H21/04 ,  C12P21/04 ,  C12N1/10 ,  C07K14/445

CPC分类号： C07K14/445 ,  A61K39/00 ,  A61K39/015 ,  A61K2039/55566 ,  Y02A50/412

摘要： Malaria in humans is caused by infection with Plasmodium species parasites including P. vivax. The biology and immunobilogy of P. vivax is distinct from that of P. falciparum. Provided are unique synthetic polypeptides and DNA molecules which encode them. Each of these molecules correspond to regions of the circumsporozoite protein of P. vivax. Each molecule comprises sequences corresponding to several repeats of the central region of the Pv 210 variant fused to sequences corresponding to several repeats of the central region of the Pv 247 variant. Each molecule additionally comprises sequences corresponding to either the amino terminus, the carboxy terminus, or both the amino and carboxy termini of the PvCSP. Also provided are vaccines comprising these unique sequences and methods of using these vaccines and sequences to prevent and treat Pv malaria.

摘要翻译： 人类的疟疾是由包括间日疟原虫在内的疟原虫寄生虫感染引起的。 间日疟原虫的生物学和免疫学不同于恶性疟原虫的生物学和免疫学。 提供了编码它们的独特的合成多肽和DNA分子。 这些分子中的每一个对应于间日疟原虫的环子孢子蛋白的区域。 每个分子包含对应于Pv 210变体的中心区域的几个重复序列的序列，其与对应于Pv 247变体的中心区域的几个重复序列融合。 每个分子另外包含对应于PvCSP的氨基末端，羧基末端或氨基和羧基末端的序列。 还提供了包含这些独特序列的疫苗和使用这些疫苗和序列来预防和治疗Pv疟疾的疫苗。