公开(公告)号：US07005430B2

公开(公告)日：2006-02-28

申请号：US10149423

申请日：2000-12-22

申请人： Kimihisa Ueno ,  Akira Ogawa ,  Yoshihisa Ohta ,  Yuji Nomoto ,  Kotaro Takasaki ,  Hideaki Kusaka ,  Hiroshi Yano ,  Chiharu Nakagawa ,  Satoshi Nakanishi

发明人： Kimihisa Ueno ,  Akira Ogawa ,  Yoshihisa Ohta ,  Yuji Nomoto ,  Kotaro Takasaki ,  Hideaki Kusaka ,  Hiroshi Yano ,  Chiharu Nakagawa ,  Satoshi Nakanishi

IPC分类号： C07D487/14 ,  C07D473/24 ,  C07D473/22 ,  A61K31/519 ,  A61P3/10

CPC分类号： C07D487/14

摘要： A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V1 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V2 represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X—Y-Z represents R1aN—C═O and R2 represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, —NR7R8, —CO2H, a lower alkoxycarbonyl group, —COHal, —CONR9R10 or —CHO, V2 may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

摘要翻译： 由式（I）表示的稠合嘌呤衍生物：化学式id =“CHEM-US-00001”num =“000”