公开(公告)号：US09125415B2

公开(公告)日：2015-09-08

申请号：US14127465

申请日：2012-07-05

申请人： Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Whitten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

发明人： Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Whitten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

IPC分类号： A01N43/82 ,  A01N43/10 ,  C07D409/14 ,  C07D417/14 ,  A01N43/647 ,  A61L2/08 ,  A61L2/16

CPC分类号： A01N43/82 ,  A01N43/10 ,  A01N43/647 ,  A61L2/084 ,  A61L2/16 ,  C07D409/14 ,  C07D417/14

摘要： Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties against S. aureus both under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.

摘要翻译： 合成含有噻吩的水溶性低聚物并进行表征。 研究了这些化合物的光物理性质; 瞬态吸收光谱法用于探测三重激发态，并且在氘代甲醇中光谱监测其对单线态氧敏化的能力。 在UV和可见光辐射下，测试了上述化合物对金黄色葡萄球菌的光活化杀生物性质。 在研究的低聚物中，发现三噻吩衍生物有效杀死细菌。

公开(公告)号：US20140341776A1

公开(公告)日：2014-11-20

申请号：US14127465

申请日：2012-07-05

申请人： Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Witten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

发明人： Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Witten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

IPC分类号： A01N43/82 ,  A61L2/08 ,  A01N43/10 ,  A61L2/16 ,  A01N43/647

CPC分类号： A01N43/82 ,  A01N43/10 ,  A01N43/647 ,  A61L2/084 ,  A61L2/16 ,  C07D409/14 ,  C07D417/14

摘要： Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties against S. aureus both under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.

摘要翻译： 合成含有噻吩的水溶性低聚物并进行表征。 研究了这些化合物的光物理性质; 瞬态吸收光谱法用于探测三重激发态，并且在氘代甲醇中光谱监测其对单线态氧敏化的能力。 在UV和可见光辐射下，测试了上述化合物对金黄色葡萄球菌的光活化杀生物性质。 在研究的低聚物中，发现三噻吩衍生物有效杀死细菌。