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公开(公告)号：US09125415B2
公开(公告)日：2015-09-08
申请号：US14127465
申请日：2012-07-05
申请人： Kirk S. Schanze , Anand Parthasarathy , Subhadip Goswami , David G. Whitten , Eunkyung Ji , Thomas S. Corbitt , Dimitri Dascier
发明人： Kirk S. Schanze , Anand Parthasarathy , Subhadip Goswami , David G. Whitten , Eunkyung Ji , Thomas S. Corbitt , Dimitri Dascier
IPC分类号： A01N43/82 , A01N43/10 , C07D409/14 , C07D417/14 , A01N43/647 , A61L2/08 , A61L2/16
CPC分类号： A01N43/82 , A01N43/10 , A01N43/647 , A61L2/084 , A61L2/16 , C07D409/14 , C07D417/14
摘要： Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties against S. aureus both under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.
摘要翻译： 合成含有噻吩的水溶性低聚物并进行表征。 研究了这些化合物的光物理性质; 瞬态吸收光谱法用于探测三重激发态，并且在氘代甲醇中光谱监测其对单线态氧敏化的能力。 在UV和可见光辐射下，测试了上述化合物对金黄色葡萄球菌的光活化杀生物性质。 在研究的低聚物中，发现三噻吩衍生物有效杀死细菌。
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公开(公告)号：US20140341776A1
公开(公告)日：2014-11-20
申请号：US14127465
申请日：2012-07-05
申请人： Kirk S. Schanze , Anand Parthasarathy , Subhadip Goswami , David G. Witten , Eunkyung Ji , Thomas S. Corbitt , Dimitri Dascier
发明人： Kirk S. Schanze , Anand Parthasarathy , Subhadip Goswami , David G. Witten , Eunkyung Ji , Thomas S. Corbitt , Dimitri Dascier
IPC分类号： A01N43/82 , A61L2/08 , A01N43/10 , A61L2/16 , A01N43/647
CPC分类号： A01N43/82 , A01N43/10 , A01N43/647 , A61L2/084 , A61L2/16 , C07D409/14 , C07D417/14
摘要： Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties against S. aureus both under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.
摘要翻译： 合成含有噻吩的水溶性低聚物并进行表征。 研究了这些化合物的光物理性质; 瞬态吸收光谱法用于探测三重激发态，并且在氘代甲醇中光谱监测其对单线态氧敏化的能力。 在UV和可见光辐射下，测试了上述化合物对金黄色葡萄球菌的光活化杀生物性质。 在研究的低聚物中，发现三噻吩衍生物有效杀死细菌。
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公开(公告)号：US20140242148A1
公开(公告)日：2014-08-28
申请号：US14233130
申请日：2012-08-03
申请人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Dimitri Dascier , Anand Parthasarathy , Thomas S. Corbitt , Kirsten Cicotte , Elizabeth LeBleu Dirk , Xuzhi Zhu
发明人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Dimitri Dascier , Anand Parthasarathy , Thomas S. Corbitt , Kirsten Cicotte , Elizabeth LeBleu Dirk , Xuzhi Zhu
CPC分类号： A01N43/90 , A01N25/34 , A01N33/12 , A01N37/10 , A01N43/10 , A61L15/20 , A61L15/46 , A61L2300/208 , A61L2300/404 , D01H7/00 , A01N59/00 , A01N2300/00
摘要： The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.
摘要翻译： 本发明提供了用于对诸如细菌等微生物侵染的表面和织物（例如无纺织物）进行净化的方法和材料。 具有共轭低聚 - （芳基/杂芳基乙炔基）结构并且包含至少一个阳离子基团的杀生物低聚物可以用于在氧气和任选地照明的情况下净化受侵染的表面。 包含具有共轭低聚 - （芳基/杂芳基乙炔基）结构并且包含至少一个阳离子基团的杀生物低聚物的纤维，其中所述低聚物与纤维形成聚合物物理缔合或共价键合或共同形成， 编织垫 通过本发明的方法制备的结合有杀生物剂的低分子化合物的杀生物无纺布垫可用于抑制伤口和外科敷料和个人卫生产品中的细菌生长。
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公开(公告)号：US10092000B2
公开(公告)日：2018-10-09
申请号：US13809573
申请日：2011-07-13
申请人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Thomas S. Corbitt , Zhijun Zhou , Dimitri Dascier , Ying Wang , Linnea K. Ista , Anand Parthasarathy , Eric H. Hill , Yanli Tang
发明人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Thomas S. Corbitt , Zhijun Zhou , Dimitri Dascier , Ying Wang , Linnea K. Ista , Anand Parthasarathy , Eric H. Hill , Yanli Tang
IPC分类号： A01N43/90 , A01N25/08 , A01N43/10 , A01N33/12 , A01N33/10 , A01N41/04 , A01N25/10 , C07D487/08 , C07C309/11 , C07C217/20 , C07D333/16 , C07D409/14
摘要： The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and antifungal activity.
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5.发明申请STRUCTURE, SYNTHESIS, AND APPLICATIONS FOR POLY (PHENYLENE) ETHYNYLENES (PPEs) 审中-公开聚（苯乙烯）乙烯（PPEs）的结构，合成和应用公开(公告)号：US20170057970A1
公开(公告)日：2017-03-02
申请号：US15348756
申请日：2016-11-10
申请人： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
发明人： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC分类号： C07D487/08 , C08G61/02 , C08G61/12 , C07C217/20
CPC分类号： A01N43/90 , A01N25/08 , A01N25/10 , A01N33/10 , A01N33/12 , A01N41/04 , A01N43/10 , C07C217/14 , C07C217/20 , C07C309/11 , C07C309/24 , C07D333/16 , C07D409/14 , C07D487/08 , C08G61/02 , C08G61/126 , C08G75/00 , C08G2261/312 , C08G2261/3223 , C08G2261/3328 , C08G2261/3422 , C08G2261/93 , Y10T442/30
摘要： The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
摘要翻译： 本公开提供了新的聚（亚苯基亚乙炔基）（PPE）化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种PPE显示抗菌，抗病毒和抗真菌活性。
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公开(公告)号：US09549549B2
公开(公告)日：2017-01-24
申请号：US14233130
申请日：2012-08-03
申请人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Dimitri Dascier , Anand Parthasarathy , Thomas S. Corbitt , Kirsten Cicotte , Elizabeth LeBleu Dirk , Xuzhi Zhu
发明人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Dimitri Dascier , Anand Parthasarathy , Thomas S. Corbitt , Kirsten Cicotte , Elizabeth LeBleu Dirk , Xuzhi Zhu
CPC分类号： A01N43/90 , A01N25/34 , A01N33/12 , A01N37/10 , A01N43/10 , A61L15/20 , A61L15/46 , A61L2300/208 , A61L2300/404 , D01H7/00 , A01N59/00 , A01N2300/00
摘要： The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.
摘要翻译： 本发明提供了用于对诸如细菌等微生物侵染的表面和织物（例如无纺织物）进行净化的方法和材料。 具有共轭低聚 - （芳基/杂芳基乙炔基）结构并且包含至少一个阳离子基团的杀生物低聚物可用于在氧气和任选地照射的情况下净化受侵染的表面。 包含具有共轭低聚 - （芳基/杂芳基乙炔基）结构并且包含至少一个阳离子基团的杀生物低聚物的纤维，其中所述低聚物与纤维形成聚合物物理缔合或共价键合或共同形成， 编织垫 通过本发明的方法制备的结合有杀生物剂的低分子化合物的杀生物无纺布垫可用于抑制伤口和外科敷料和个人卫生产品中的细菌生长。
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7.发明授权Structure, synthesis, and applications for poly (phenylene) ethynylenes (PPEs) 有权聚（亚苯基）乙炔（PPEs）的结构，合成和应用公开(公告)号：US09527806B2
公开(公告)日：2016-12-27
申请号：US13809572
申请日：2011-07-13
申请人： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
发明人： David G. Whitten , Kirk S. Schanze , Anand Parthasarathy , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista , Eric H. Hill
IPC分类号： C07C229/00 , C07C309/24 , C07C217/14 , C07C309/11 , C07C217/20 , C07D333/16 , C07D487/08 , C08G61/02 , C08G75/00
CPC分类号： C07D487/08 , C07C217/14 , C07C217/20 , C07C309/11 , C07C309/24 , C07D333/16 , C08G61/02 , C08G61/126 , C08G75/00 , C08G2261/312 , C08G2261/3223 , C08G2261/3328 , C08G2261/3422 , C08G2261/93
摘要： The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
摘要翻译： 本公开提供了新的聚（亚苯基亚乙炔基）（PPE）化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种PPE显示抗菌，抗病毒和抗真菌活性。
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8.发明申请STRUCTURE, SYNTHESIS, AND APPLICATIONS FOR OLIGO PHENYLENE ETHYNYLENES (OPEs) 审中-公开低聚苯乙烯（OPE）的结构，合成及应用公开(公告)号：US20130273800A1
公开(公告)日：2013-10-17
申请号：US13809573
申请日：2011-07-13
申请人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Thomas S. Corbitt , Zhijun Zhou , Dimitri Dascier , Ying Wang , Linnea K. Ista , Anand Parthsaray
发明人： David G. Whitten , Kirk S. Schanze , Eunkyung Ji , Thomas S. Corbitt , Zhijun Zhou , Dimitri Dascier , Ying Wang , Linnea K. Ista , Anand Parthsaray
CPC分类号： A01N43/90 , A01N25/08 , A01N25/10 , A01N33/10 , A01N33/12 , A01N41/04 , A01N43/10 , C07C217/20 , C07C309/11 , C07D333/16 , C07D409/14 , C07D487/08 , Y10T442/30
摘要： The present disclosure provides novel oligo phenylene ethynylene (OPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various OPEs show antibacterial, antiviral and anti-fungal activity.
摘要翻译： 本公开提供了新的低聚亚苯基亚乙炔（OPE）化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种OPE显示抗菌，抗病毒和抗真菌活性。
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9.发明申请STRUCTURE, SYNTHESIS, AND APPLICATIONS FOR POLY (PHENYLENE) ETHYNYLENES (PPEs) 有权聚（苯乙烯）乙烯（PPEs）的结构，合成和应用公开(公告)号：US20130210828A1
公开(公告)日：2013-08-15
申请号：US13809572
申请日：2011-07-13
申请人： David G. Whitten , Kirk S. Sehanze , Anand Parthsaray , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista
发明人： David G. Whitten , Kirk S. Sehanze , Anand Parthsaray , Eunkyung Ji , Motokatsu Ogawa , Thomas S. Corbitt , Dimitri Dascier , Ying Wang , Linnea K. Ista
IPC分类号： C07C309/24 , C07D333/16 , C07D487/08 , C07C217/20 , C08G61/02 , C08G75/00
CPC分类号： C07D487/08 , C07C217/14 , C07C217/20 , C07C309/11 , C07C309/24 , C07D333/16 , C08G61/02 , C08G61/126 , C08G75/00 , C08G2261/312 , C08G2261/3223 , C08G2261/3328 , C08G2261/3422 , C08G2261/93
摘要： The present disclosure provides novel poly(phenylene ethynylene) (PPE) compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various PPEs show antibacterial, antiviral and antifungal activity.
摘要翻译： 本公开提供了新的聚（亚苯基亚乙炔基）（PPE）化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种PPE显示抗菌，抗病毒和抗真菌活性。
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公开(公告)号：US20130330386A1
公开(公告)日：2013-12-12
申请号：US13993026
申请日：2011-12-12
IPC分类号： A01N41/04
CPC分类号： A01N41/04 , A01N33/12 , C08F230/08 , A01N25/10 , A01N37/38
摘要： The present disclosure provides novel polyampholyte compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various polyampholytes show antibacterial activity and may also demonstrate antiviral antifungal and/or antibiofilm activity.
摘要翻译： 本公开提供了新的聚阴离子化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种多聚电解质显示抗菌活性，并且还可以显示抗病毒抗真菌和/或抗菌膜活性。
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