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![ENANTIOMERIC COMPOSITIONS OF 2-AMINO-1-(2-ISOPROPYLPYRAZOLO[1,5-a]PYRIDIN-3-YL)PROPAN-1-ONE AND RELATED METHODS](/abs-image/US/2010/12/23/US20100324082A1/abs.jpg.150x150.jpg)
1.发明申请ENANTIOMERIC COMPOSITIONS OF 2-AMINO-1-(2-ISOPROPYLPYRAZOLO[1,5-a]PYRIDIN-3-YL)PROPAN-1-ONE AND RELATED METHODS 失效2-氨基-1-（2-异丙基吡唑并[1,5-a]吡啶-3-YL）的丙酮组合物和相关方法公开(公告)号：US20100324082A1
公开(公告)日：2010-12-23
申请号：US12820993
申请日：2010-06-22
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00 , A61P19/02 , A61P1/00 , A61P3/10 , A61P37/06 , A61P11/06 , A61P17/00
CPC分类号： C07D471/04 , A61K31/437 , C07B2200/07
摘要： Enantiomerically pure (S)-2-amino-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one, (S)-AV1013, is a candidate therapeutic for treating neuroathic pain, addiction behavior and drug withdrawal symptoms. Also described are methods for preparing and using (S)-AV1013, its pharmaceutically acceptable salts as well as pharmaceutically acceptable formulations of the same.
摘要翻译： 对映体纯的（S）-2-氨基-1-（2-异丙基吡唑并[1,5-a]吡啶-3-基）丙-1-酮，（S）-AV1013是治疗神经性疼痛的候选治疗剂， 成瘾行为和戒毒症状。 还描述了制备和使用（S）-AV1013，其药学上可接受的盐以及其药学上可接受的制剂的方法。
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![Enantiomeric compositions of 2-amino-1-(2-isopropylpyrazolo[1,5-α]pyridin-3-yl)propan-1-one and related methods](/abs-image/US/2012/02/21/US08119657B2/abs.jpg.150x150.jpg)
2.发明授权Enantiomeric compositions of 2-amino-1-(2-isopropylpyrazolo[1,5-α]pyridin-3-yl)propan-1-one and related methods 失效2-氨基-1-（2-异丙基吡唑并[1,5-a]吡啶-3-基）丙-1-酮的对映体组合物及相关方法公开(公告)号：US08119657B2
公开(公告)日：2012-02-21
申请号：US12820993
申请日：2010-06-22
IPC分类号： A61K31/44 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , A61K31/437 , C07B2200/07
摘要： Enantiomerically pure (S)-2-amino-1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one, (S)-AV1013, is a candidate therapeutic for treating neuropathic pain, addiction behavior and drug withdrawal symptoms. Also described are methods for preparing and using (S)-AV1013, its pharmaceutically acceptable salts as well as pharmaceutically acceptable formulations of the same.
摘要翻译： 对映体纯的（S）-2-氨基-1-（2-异丙基吡唑并[1,5-a]吡啶-3-基）丙-1-酮，（S）-AV1013是治疗神经性疼痛的候选治疗剂， 成瘾行为和戒毒症状。 还描述了制备和使用（S）-AV1013，其药学上可接受的盐以及其药学上可接受的制剂的方法。
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公开(公告)号：US20180055842A1
公开(公告)日：2018-03-01
申请号：US15685566
申请日：2017-08-24
IPC分类号： A61K31/501 , A61K31/337 , A61K45/06
CPC分类号： A61K31/501 , A61K31/138 , A61K31/337 , A61K31/38 , A61K31/4196 , A61K31/433 , A61K31/454 , A61K31/513 , A61K31/555 , A61K31/675 , A61K31/69 , A61K31/704 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.
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公开(公告)号：US20150258082A1
公开(公告)日：2015-09-17
申请号：US14657584
申请日：2015-03-13
申请人： Francesco Parlati , Mirna L. Rodriguez , Matthew I. Gross , Terri L. Davis , Jim Li , Lijing Chen , Bindu Goyal , Guy Laidig , Timothy F. Stanton , Eric B. Sjogren
发明人： Francesco Parlati , Mirna L. Rodriguez , Matthew I. Gross , Terri L. Davis , Jim Li , Lijing Chen , Bindu Goyal , Guy Laidig , Timothy F. Stanton , Eric B. Sjogren
IPC分类号： A61K31/454 , A61K31/4402 , A61K31/573
CPC分类号： A61K31/454 , A61K31/4035 , A61K31/4402 , A61K31/501 , A61K31/517 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The invention relates to methods of treating cancer, myeloproliferative disorders or immunological diseases with a combination of an immunomodulatory agent and a glutaminase inhibitor. The invention further relates to methods of treating cancer, myeloproliferative disorders, or immunological diseases that are resistant to one or more immunomodulatory agents.
摘要翻译： 本发明涉及通过免疫调节剂和谷氨酰胺酶抑制剂的组合治疗癌症，骨髓增生性疾病或免疫疾病的方法。 本发明还涉及治疗对一种或多种免疫调节剂具有抗性的癌症，骨髓增生性疾病或免疫疾病的方法。
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