公开(公告)号：US20050124699A1

公开(公告)日：2005-06-09

申请号：US11025990

申请日：2005-01-03

申请人： Kiyoshi Akiba ,  Futoshi Hoshina ,  Mitsuzi Agata

发明人： Kiyoshi Akiba ,  Futoshi Hoshina ,  Mitsuzi Agata

IPC分类号： A61K9/00 ,  A61K31/196 ,  A61K31/5575 ,  A61K45/06 ,  A61K31/557

CPC分类号： A61K45/06 ,  A61K9/0048 ,  A61K31/196 ,  A61K31/5575 ,  A61K2300/00

摘要： The present invention provides an eye drop for treating or preventing disorders of corneal and/or conjunctival epithelial cells comprising prostaglandin E's as effective components; and an eye drop for treating or preventing disorders of corneal and/or conjunctival epithelial cells comprising prostaglandin E's and an anti-inflammatory agent as effective components. The eye drop shows a high effect of treating and/or preventing disorders of cornea or conjunctiva originated from physical, chemical and/or mechanical damages of the cornea or conjunctiva as well as endogenous disorders of cornea or conjunctiva.

摘要翻译： 本发明提供了用于治疗或预防包含前列腺素E作为有效成分的角膜和/或结膜上皮细胞疾病的滴眼剂; 以及用于治疗或预防包含前列腺素E和抗炎剂作为有效成分的角膜和/或结膜上皮细胞疾病的眼药水。 眼药水显示出治疗和/或预防由于角膜或结膜的物理，化学和/或机械损伤以及角膜或结膜的内源性障碍引起的角膜或结膜疾病的高效果。

公开(公告)号：USRE35281E

公开(公告)日：1996-06-18

申请号：US178666

申请日：1994-01-07

申请人： Sinji Inukai ,  Mitsuzi Agata ,  Kiyoshi Akiba ,  Takeo Ohmura ,  Yoshihiro Horio ,  Yasuhiro Ootake ,  Shohei Sawaki ,  Masayoshi Goto

发明人： Sinji Inukai ,  Mitsuzi Agata ,  Kiyoshi Akiba ,  Takeo Ohmura ,  Yoshihiro Horio ,  Yasuhiro Ootake ,  Shohei Sawaki ,  Masayoshi Goto

IPC分类号： C07D257/04 ,  A61K31/41

CPC分类号： C07D257/04

摘要： The present invention relates to an aldose reductase inhibitor having the following formula: ##STR1## R.sub.1 is a hydrogen atom or --A--COOR.sub.5 (A is an alkylene group having 1 to 4 carbon atoms and R.sub.5 is a hydrogen atom or a lower alkyl group), and R.sub.2, R.sub.3 and R.sub.4 are the same as or different from each other and selected from the group consisting of a hydrogen atom, a hydroxy group, a halogen atom, a carboxyl group, an alkyl group, an amide group, an amino group, an alkoxy group, an aryl group, an aryloxy group, an alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, a nitro group, --NHCOCOOR.sub.6 (R.sub.6 is a hydrogen atom or a lower alkyl group), a mono- or dialkylaminosulfonyl group, and a residual group having the following formula: ##STR2## (A and R.sub.5 are the same as in the above). The compounds defined in the above are excellent in aldose reductase inhibitory activity and low in toxicity. Therefore, those compounds are useful as a preventive agent and/or a remedy for diabetic complications such as neuropathy, retinopathy, nephropathy, cataracts and keratopathy.

摘要翻译： 本发明涉及具有下式的醛糖还原酶抑制剂：其中R 1为氢原子或-A-COOR 5（A为碳原子数为1〜4的亚烷基，R 5为氢原子或低级烷基 ），R2，R3和R4彼此相同或不同，并且选自氢原子，羟基，卤素原子，羧基，烷基，酰胺基，氨基 基团，烷氧基，芳基，芳氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，硝基，-NHCOCOOR6（R6是氢原子或低级烷基），单或二烷基氨基磺酰基 基团和具有下式的残基：（A和R5与上述相同）。 上述定义的化合物具有优异的醛糖还原酶抑制活性和低毒性。 因此，这些化合物可用作糖尿病并发症如神经病，视网膜病，肾病，白内障和角膜病的预防剂和/或补救剂。

公开(公告)号：US5055481A

公开(公告)日：1991-10-08

申请号：US497500

申请日：1990-03-22

申请人： Sinji Inukai ,  Mitsuzi Agata ,  Kiyoshi Akiba ,  Takeo Ohmura ,  Yoshihiro Horio ,  Yasuhiro Ootake ,  Shohei Sawaki ,  Masayoshi Goto

发明人： Sinji Inukai ,  Mitsuzi Agata ,  Kiyoshi Akiba ,  Takeo Ohmura ,  Yoshihiro Horio ,  Yasuhiro Ootake ,  Shohei Sawaki ,  Masayoshi Goto

IPC分类号： C07D257/04

CPC分类号： C07D257/04

摘要： The present invention relates to an aldose reductase inhibitor having the following formula: ##STR1## R.sub.1 is a hydrogen atom or --A--COOR.sub.5 (A is an alkylene group having 1 to 4 carbon atoms and R.sub.5 is a hydrogen atom or a lower alkyl group), and R.sub.2, R.sub.3 and R.sub.4 are the same as or different from each other and selected from the group consisting of a hydrogen atom, a hydroxy group, a halogen atom, a carboxyl group, an alkyl group, an amide group, an amino group, an alkoxy group, an aryl group, an aryloxy group, an alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, a nitro group, --NHCOCOOR.sub.6 (R.sub.6 is a hydrogen atom or a lower alkyl group), a mono- or dialkylaminosulfonyl group, and a residual group having the following formula: ##STR2## (A and R.sub.5 are the same as in the above). The compounds defined in the above are excellent in aldose reductase inhibitory activity and low in toxicity. Therefore, those compounds are useful as a preventive agent and/or a remedy for diabetic complications such as neuropathy, retinopathy, nephropathy, cataracts and keratopathy.

公开(公告)号：US5252592A

公开(公告)日：1993-10-12

申请号：US821456

申请日：1992-01-16

申请人： Sinji Inukai ,  Mitsuzi Agata ,  Kiyoshi Akiba ,  Takeo Ohmura ,  Yoshihiro Horio ,  Yasuhiro Ootake ,  Shohei Sawaki ,  Masayoshi Goto

发明人： Sinji Inukai ,  Mitsuzi Agata ,  Kiyoshi Akiba ,  Takeo Ohmura ,  Yoshihiro Horio ,  Yasuhiro Ootake ,  Shohei Sawaki ,  Masayoshi Goto

IPC分类号： A61K31/41 ,  A61P43/00 ,  C07D257/04

CPC分类号： C07D257/04

摘要： A tetrazoleacetic acid derivative represented by the following general formula (I): ##STR1## [in Formula (I), R.sub.1 represents a hydrogen atom or a lower alkyl group; R.sub.2, R.sub.3 and R.sub.4 are the same or different from each other and are selected from the group consisting of hydrogen, lower alkyl, halogen, lower haloalkyl, hydroxy and lower alkoxy; and tetrazol group is substituted at 1- or 2-position of naphthyl group] except for [5-(1-naphthyl)tetrazol-1-yl]acetic acid and ethyl ester thereof, or a salt thereof.

公开(公告)号：US4445399A

公开(公告)日：1984-05-01

申请号：US289311

申请日：1981-07-30

申请人： Takeshi Sasaki ,  Kiyoshi Akiba ,  Yoshio Takahashi

发明人： Takeshi Sasaki ,  Kiyoshi Akiba ,  Yoshio Takahashi

IPC分类号： F16F15/26 ,  F16C3/20 ,  F16F15/28 ,  G01M1/24 ,  G01M1/32 ,  B23K1/20 ,  B23K27/00

CPC分类号： F16C3/20 ,  F16F15/283 ,  G01M1/24 ,  G01M1/32 ,  Y10T29/49286 ,  Y10T74/2183

摘要： A process for balancing a crankshaft comprising applying balancing masses onto the outer peripheral surfaces of balancing weight parts of a crankshaft, by welding, in accordance with the degree of unbalance of the shaft and preliminarily forming recesses or projecting portions at positions radially inward of the balancing masses applied by welding to prevent transmission of thermal stress to central journal parts of the crankshaft and thereby preclude bending of the shaft.

摘要翻译： 一种用于平衡曲轴的方法，包括根据轴的不平衡程度，通过焊接将平衡块施加到曲轴的平衡配重部件的外周面上，并且在平衡的径向内侧的位置预先形成凹部或突出部分 通过焊接施加的质量以防止热应力传递到曲轴的中心轴颈部分，从而排除轴的弯曲。