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6 条记录 (耗时 0.026 秒)

    Benzoic acid compounds and use thereof as medicaments
    2.
    发明授权
    Benzoic acid compounds and use thereof as medicaments 失效
    苯甲酸化合物及其作为药物的用途

    公开(公告)号：US5864039A

    公开(公告)日：1999-01-26

    申请号：US982389

    申请日：1997-12-02

    申请人： Takeshi Kawakita ,  Takanobu Kuroita ,  Takahiro Murozono ,  Hidetoshi Hakira ,  Keiichiro Haga ,  Katsuhiko Ito ,  Shuji Sonda ,  Toshio Kawahara ,  Kiyoshi Asano

    发明人： Takeshi Kawakita ,  Takanobu Kuroita ,  Takahiro Murozono ,  Hidetoshi Hakira ,  Keiichiro Haga ,  Katsuhiko Ito ,  Shuji Sonda ,  Toshio Kawahara ,  Kiyoshi Asano

    IPC分类号： C07D221/02 ,  C07D265/14

    CPC分类号： C07D221/02 ,  C07D265/14

    摘要： Benzoic acid compounds of the formula ##STR1## wherein each symbol is as defined in the specification, optical isomers thereof and pharmaceutically acceptable salts thereof; pharmaceutical composition comprising this compound and pharmaceutically acceptable additive; and serotonin 4 receptor agonists, gastrointestinal prokinetic agents and therapeutic agents for various gastrointestinal diseases, which comprise this compound as active ingredient. The compounds of the present invention have high and selective affinity for serotonin 4 receptor, and show agonistic effects thereon. Accordingly, they are useful medications for the prophylaxis and treatment of various gastrointestinal diseases, central nervous disorders, cardiac function disorders, urinary diseases, and the like, as well as useful anti-nociceptors for analgesic use which increase threshold of pain.

    摘要翻译： 式（I）的苯甲酸化合物，其中每个符号如说明书中所定义，其光学异构体和其药学上可接受的盐; 包含该化合物和药学上可接受的添加剂的药物组合物; 和5-羟色胺4受体激动剂，胃肠促动素和各种胃肠道疾病的治疗剂，其包含该化合物作为活性成分。 本发明化合物对5-羟色胺4受体具有高选择性的亲和力，并且对其表现出激动作用。 因此，它们是用于预防和治疗各种胃肠道疾病，中枢神经障碍，心脏功能障碍，尿病等的有用药物，以及增加疼痛阈值的有用的止痛药用抗伤害感受器。

    Method for prophylaxis and treatment of irritable bowel syndrome
    3.
    发明授权
    Method for prophylaxis and treatment of irritable bowel syndrome 失效
    肠易激综合征预防和治疗方法

    公开(公告)号：US5965557A

    公开(公告)日：1999-10-12

    申请号：US167566

    申请日：1998-10-07

    申请人： Kiyoshi Asano ,  Shigemi Kino ,  Hiroshi Yasumatsu

    发明人： Kiyoshi Asano ,  Shigemi Kino ,  Hiroshi Yasumatsu

    IPC分类号： A61K31/495

    CPC分类号： A61K31/495

    摘要： A method for the prophylaxis and treatment of irritable bowel syndrome, which comprises administering a pharmaceutically effective amount of at least one compound selected from the group consisting of (.+-.)-2-(4-chlorophenyl)-5,6-dihydro-[1]benzothiepino [5,4-c]pyridazin-3(2H)-one 7-oxide, optical isomers thereof and 2-(4-chlorophenyl)-5,6-dihydro-[1]benzothiepino[5,4-c]pyridazin-3(2H)-one 7,7-dioxide to a subject in need of such prophylaxis or treatment.

    摘要翻译： 一种预防和治疗肠易激综合征的方法，其包括给予药学上有效量的至少一种选自（+/-） - （ - （4-氯苯基）-5,6-二氢 - [1]苯并噻吩并[5,4-c]哒嗪-3（2H） - 酮7-氧化物，其光学异构体和2-（4-氯苯基）-5,6-二氢 - [1]苯并噻吩并[5,4- c]哒嗪-3（2H） - 酮7,7-二氧化物施用于需要这种预防或治疗的受试者。

    X-ray diagnostic device with safe and durable X-ray tube suspension mechanism
    4.
    发明授权
    X-ray diagnostic device with safe and durable X-ray tube suspension mechanism 失效
    X射线诊断仪具有安全耐用的X射线管悬挂机构

    公开(公告)号：US5037059A

    公开(公告)日：1991-08-06

    申请号：US367346

    申请日：1989-06-16

    申请人： Kiyoshi Asano ,  Kiyoaki Inoue ,  Shunichiro Nishigaki

    发明人： Kiyoshi Asano ,  Kiyoaki Inoue ,  Shunichiro Nishigaki

    IPC分类号： A61B6/00

    CPC分类号： A61B6/447

    摘要： An X-ray diagnostic device with a suspension mechanism for suspending an object in a vertically movable manner, using two suspension wires, which can avoid the shortened durability of the suspension wires, and using windup type springs, which can eliminate possibility for the fall of the suspended object due to the breaking of the windup type springs. The suspension mechanism may includes two suspension wires for holding the suspended object; and single threaded corn pulleys, one for each one of the two suspension wires, for winding the respective suspension wires. The suspension mechanism may also includes a plurality of windup type springs for balancing against gravitational force acting on the suspended object; connection between the plurality of windup type springs such that this connection moves when the plurality of windup type springs are put to be not balanced with respect to each other; and mechanism for preventing the fall of the suspended object by detecting motion of the connection.

    摘要翻译： 一种具有悬挂机构的X射线诊断装置，其使用两根悬挂线垂直移动，能够避免悬挂线的耐久性降低，并且能够消除掉落的可能性， 悬挂物体由于破碎型弹簧而产生。 悬挂机构可以包括用于保持悬挂物体的两个悬挂线; 和单螺纹玉米皮带轮，一个用于两根悬挂线中的每一根，用于缠绕相应的悬挂线。 悬架机构还可以包括多个卷绕型弹簧，用于平衡作用在悬挂物体上的重力; 多个卷绕型弹簧之间的连接，使得当多个卷绕型弹簧相对于彼此不平衡时，该连接移动; 以及用于通过检测连接的运动来防止悬挂物体的下落的机构。

    Process for producing magnetic powder and product
    6.
    发明授权
    Process for producing magnetic powder and product 失效
    磁粉和制品生产工艺

    公开(公告)号：US4539261A

    公开(公告)日：1985-09-03

    申请号：US482225

    申请日：1983-04-05

    申请人： Kazuo Nakata ,  Masatsuyo Maruo ,  Kiyoshi Asano

    发明人： Kazuo Nakata ,  Masatsuyo Maruo ,  Kiyoshi Asano

    IPC分类号： H01F1/11 ,  C09C1/24 ,  G11B5/706 ,  B32B3/16

    CPC分类号： C09C1/24 ,  G11B5/70657 ,  C01P2006/12 ,  C01P2006/42 ,  Y10T428/2991

    摘要： A process for producing a magnetic powder which comprises coating the particle surfaces of a magnetic iron oxide with a cobalt compound or a cobalt compound and a ferrous compound and further coating with a compound of at least one metal selected from the group consisting of manganese, vanadium and zinc. There is obtained a magnetic powder having high coercivity and excellent dispersibility in organic binders. This magnetic powder is useful as a material for recording media such as magnetic tapes.

    摘要翻译： 一种制造磁粉的方法，包括用钴化合物或钴化合物和亚铁化合物涂覆磁性氧化铁的颗粒表面，并进一步用至少一种选自锰，钒的金属的化合物 和锌。 得到矫顽磁力高，分散性好的有机粘结剂的磁性粉末。 该磁性粉末作为用于记录诸如磁带的介质的材料是有用的。