公开(公告)号：US5500416A

公开(公告)日：1996-03-19

申请号：US120141

申请日：1993-09-10

申请人： Kiyoshi Miyazawa ,  Tadahiro Chiba ,  Yuhei Iwata ,  Uhei Tamura ,  Isao Murotani ,  Shuya Tamaki

发明人： Kiyoshi Miyazawa ,  Tadahiro Chiba ,  Yuhei Iwata ,  Uhei Tamura ,  Isao Murotani ,  Shuya Tamaki

IPC分类号： A61K47/06 ,  A61K9/00 ,  A61K47/00 ,  A61K47/18 ,  A61K31/70 ,  A61K31/40 ,  A61K31/505 ,  A61K31/52 ,  A61K31/56 ,  A61K31/66

CPC分类号： A61K9/0014 ,  A61K47/18 ,  Y10S514/947 ,  Y10S514/975

摘要： A percutaneous absorption promoting agent comprising (A) at least one anionic surfactant and one or two or more of surfactants having a nitrogen atom in the molecule other than anionic surfactants, (B) one or two or more of anionic surfactants and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, (C) one or two or more of surfactants selected from the group consisting of amphoteric surfactant and semi-polar surfactants and at least one nonionic surfactant having a nitrogen atom in the molecule, (D) one or two or more of surfactants selected from the group consisting of nonionic surfactants, amphoteric surfactants, semi-polar surfactants and cationic surfactants having a nitrogen atom in the molecule, and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, or (E) an amine oxide as the active ingredient, and a dermatological preparation containing these percutaneous absorption promoting agent and drug components.

摘要翻译： 一种经皮吸收促进剂，其包含（A）至少一种阴离子表面活性剂和除了阴离子表面活性剂之外的分子中具有氮原子的一种或两种以上的表面活性剂，（B）一种或两种以上阴离子表面活性剂和一种或两种或 更多的分子中不具有氮原子的非离子表面活性剂，（C）一种或两种以上选自两性表面活性剂和半极性表面活性剂的表面活性剂和至少一种在分子中具有氮原子的非离子表面活性剂， （D）选自非离子表面活性剂，两性表面活性剂，半极性表面活性剂和分子中具有氮原子的阳离子表面活性剂中的一种或两种以上的表面活性剂，以及一种或两种以上不含氮的非离子表面活性剂 分子中的原子，或（E）作为活性成分的氧化胺，以及含有这些经皮吸收促进剂和药物成分的皮肤病学制剂。

公开(公告)号：US5120716A

公开(公告)日：1992-06-09

申请号：US298610

申请日：1988-10-05

申请人： Kiyoshi Miyazawa ,  Tadahiro Chiba ,  Yuhei Iwata ,  Uhei Tamura ,  Isao Murotani ,  Shuya Tamaki

发明人： Kiyoshi Miyazawa ,  Tadahiro Chiba ,  Yuhei Iwata ,  Uhei Tamura ,  Isao Murotani ,  Shuya Tamaki

IPC分类号： A61K47/06 ,  A61K9/00 ,  A61K47/00 ,  A61K47/18

CPC分类号： A61K9/0014 ,  A61K47/18 ,  Y10S514/947 ,  Y10S514/975

摘要： A percutaneous absorption promoting agent comprising (A) at least one anionic surfactant and one or two or more of surfactants having a nitrogen atom in the molecule other than anionic surfactants, (B) one or two or more of anionic surfactants and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, (C) one or two or more of surfactants selected from the group consisting of amphoteric surfactant and semi-polar surfactants and at least one nonionic surfactant having a nitrogen atom in the molecule, (D) one or two or more of surfactants selected from the group consisting of nonionic surfactants, amphoteric surfactants, semi-polar surfactants and cationic surfactants having a nitrogen atom in the molecule, and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, or (E) an amine oxide as the active ingredient, and a dermatological preparation containing these percutaneous absorption promoting agent and drug components.

公开(公告)号：US5733891A

公开(公告)日：1998-03-31

申请号：US380324

申请日：1995-01-30

申请人： Kazuo Akima ,  Yuhei Iwata ,  Kayoko Matsuo ,  Nobutoshi Watari

发明人： Kazuo Akima ,  Yuhei Iwata ,  Kayoko Matsuo ,  Nobutoshi Watari

IPC分类号： A61K47/48 ,  A61K31/70 ,  C07H1/00 ,  C07H15/00

CPC分类号： A61K47/4823

摘要： A compound of hyaluronic acid and a medicinal ingredient produced by the convalent bonding (preferably amide bonding) of hyaluronic acid and the medicinal ingredient, and a process for preparing the same. The hyaluronic acid portion is completely decomposed by metabolism in the action region, whereby the medicinal ingredient is gradually and quantitatively released.

摘要翻译： 透明质酸的化合物和通过透明质酸的共价键合（优选酰胺键合）和药用成分而得到的药物成分及其制备方法。 透明质酸部分通过动作区域中的代谢完全分解，药物成分逐渐和定量地释放。