公开(公告)号：US20180369237A1

公开(公告)日：2018-12-27

申请号：US16116282

申请日：2018-08-29

申请人： Klaus WENING ,  ANJA GEIßLER ,  JANA DENKER ,  LUTZ BARNSCHEID

发明人： Klaus WENING ,  ANJA GEIßLER ,  JANA DENKER ,  LUTZ BARNSCHEID

IPC分类号： A61K31/485 ,  A61K9/16 ,  A61K9/20 ,  A61K31/137 ,  A61K9/50 ,  A61K9/48

摘要： A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.