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    Tamper Resistant Dosage Form Comprising An Anionic Polymer
    1.
    发明申请
    Tamper Resistant Dosage Form Comprising An Anionic Polymer 有权
    包含阴离子聚合物的防篡改剂型

    公开(公告)号：US20120065220A1

    公开(公告)日：2012-03-15

    申请号：US13223384

    申请日：2011-09-01

    申请人： Lutz BARNSCHEID ,  Sebastian SCHWIER ,  Johannes BARTHOLOMÄUS

    发明人： Lutz BARNSCHEID ,  Sebastian SCHWIER ,  Johannes BARTHOLOMÄUS

    IPC分类号： A61K31/485 ,  A61K31/135 ,  A61P25/04 ,  A61K47/34

    CPC分类号： A61K9/2031 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/137

    摘要： A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); a physiologically acceptable polymer (B) obtainable by polymerization of a monomer composition comprising an ethylenically unsaturated monomer bearing an anionic functional group, in protonated form or a physiologically acceptable salt thereof; a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the polymer (B) and the polyalkylene oxide (C).

    摘要翻译： 一种药物剂型及其使用方法，所述药物剂型具有至少500N的断裂强度，所述剂型含有药理活性成分（A）; 通过聚合包含具有阴离子官能团的烯属不饱和单体，质子化形式的单体组合物或其生理学上可接受的盐得到的生理上可接受的聚合物（B） 重均分子量至少为200,000g / mol的聚环氧烷（C），其中聚环氧烷（C）的含量为至少20重量％，基于剂型的总重量; 其中药理活性成分（A）存在于包含聚合物（B）和聚环氧烷（C）的控释基质中。

    HOT-MELT EXTRUDED PHARMACEUTICAL DOSAGE FORM
    4.
    发明申请
    HOT-MELT EXTRUDED PHARMACEUTICAL DOSAGE FORM 审中-公开
    热熔制品药物剂型

    公开(公告)号：US20110038930A1

    公开(公告)日：2011-02-17

    申请号：US12840439

    申请日：2010-07-21

    申请人： Lutz BARNSCHEID ,  Eric Galia

    发明人： Lutz BARNSCHEID ,  Eric Galia

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K31/133 ,  A61P25/04 ,  B29C69/02

    CPC分类号： A61K9/2072 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/137

    摘要： The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled release of a pharmacologically active ingredient (A) embedded in a matrix comprising a polymer (C), the dosage form exhibiting a breaking strength of at least 300 N and having an oblong shape comprising a longitudinal direction of extension, a transversal direction of extension orthogonal to the longitudinal direction of extension, a front side, an opposite back side and a circumferential rim between said front and back side;wherein the core of the pharmaceutical dosage form has a morphological orientation caused by hot-melt extrusion that is substantially orthogonal to the longitudinal direction of extension of the dosage form; and/or the release per area of the pharmacologically active ingredient (A) through the front side and the opposite back side is faster than the release through the circumferential rim.

    摘要翻译： 本发明涉及一种具有控制释放包含聚合物（C）的基质中的药理学活性成分（A）的热熔挤出药物剂型，所述剂型具有至少300N的断裂强度并且具有长方形 形状，其包括纵向延伸方向，垂直于所述纵向延伸方向的横向方向，所述前侧和后侧之间的前侧，相对的后侧和周向边缘; 其中所述药物剂型的核心具有由与所述剂型的延伸长度方向基本正交的热熔融挤出引起的形态取向; 和/或通过前侧和相对背侧的药理活性成分（A）的每个面积的释放比通过周缘的释放快。

    Tamper Resistant Dosage Form Comprising An Anionic Polymer
    7.
    发明申请
    Tamper Resistant Dosage Form Comprising An Anionic Polymer 审中-公开
    包含阴离子聚合物的防篡改剂型

    公开(公告)号：US20120059065A1

    公开(公告)日：2012-03-08

    申请号：US13223358

    申请日：2011-09-01

    申请人： Lutz Barnscheid ,  Sebastian Schwier ,  Johannes Bartholomäus

    发明人： Lutz Barnscheid ,  Sebastian Schwier ,  Johannes Bartholomäus

    IPC分类号： A61K31/135 ,  A61P25/04

    CPC分类号： A61K31/137 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2095

    摘要： A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an anionic polysaccharide (B) obtainable by introducing anionic functional groups, in protonated form or a physiologically acceptable salt thereof, into a polysaccharide; and a polyalkylene oxide (C); wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the anionic polysaccharide (B) and the polyalkylene oxide (C).

    摘要翻译： 一种药物剂型及其使用方法，所述药物剂型具有至少500N的断裂强度，所述剂型含有药理活性成分（A）; 通过将质子化形式的阴离子官能团或其生理上可接受的盐引入多糖中获得的阴离子多糖（B） 和聚环氧烷（C）; 其中药理活性成分（A）存在于包含阴离子多糖（B）和聚环氧烷（C）的控释基质中。

    Hot-melt extruded pharmaceutical dosage form
    9.
    发明授权
    Hot-melt extruded pharmaceutical dosage form 有权

    公开(公告)号：US10080721B2

    公开(公告)日：2018-09-25

    申请号：US12840439

    申请日：2010-07-21

    申请人： Lutz Barnscheid ,  Eric Galia

    发明人： Lutz Barnscheid ,  Eric Galia

    IPC分类号： A61K9/22 ,  A61K9/20 ,  A61K31/137

    CPC分类号： A61K9/2072 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/137

    摘要： The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled release of a pharmacologically active ingredient (A) embedded in a matrix comprising a polymer (C), the dosage form exhibiting a breaking strength of at least 300 N and having an oblong shape comprising a longitudinal direction of extension, a transversal direction of extension orthogonal to the longitudinal direction of extension, a front side, an opposite back side and a circumferential rim between said front and back side;wherein the core of the pharmaceutical dosage form has a morphological orientation caused by hot-melt extrusion that is substantially orthogonal to the longitudinal direction of extension of the dosage form; and/or the release per area of the pharmacologically active ingredient (A) through the front side and the opposite back side is faster than the release through the circumferential rim.