公开(公告)号：US5034390A

公开(公告)日：1991-07-23

申请号：US414114

申请日：1989-09-28

申请人： Knut G. Olsson ,  Aina L. Abramo ,  Erik T. Lundstedt ,  Curt Nordvi

发明人： Knut G. Olsson ,  Aina L. Abramo ,  Erik T. Lundstedt ,  Curt Nordvi

IPC分类号： A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/496 ,  A61K31/505 ,  A61K31/535 ,  A61K31/55 ,  A61K31/551 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D213/60 ,  C07D213/73 ,  C07D213/74 ,  C07D213/82 ,  C07D239/04 ,  C07D239/42 ,  C07D295/04 ,  C07D401/04 ,  C07D403/04

CPC分类号： C07D213/73 ,  C07D213/82 ,  C07D239/42

摘要： The present invention concerns novel compounds of the general formula; ##STR1## wherein R.sub.1 is halogen or hydrogen and R.sub.2 is halogen; X is either oxygen, sulfor or methyleneR.sub.3 and R.sub.4 are the same or different and selected from hydrogen and lower alkyl;n is 2 or 3;A is selected from the following pyrimidyl or pyridyl groups ##STR2## wherein R.sub.5 is selected from hydrogen, lower alkyl or halogen; R.sub.6 and R.sub.7 are the same or different and selected from hydrogen, halogen, lower alkyl, electron donor groups such as lower alkoxy or hydroxy, electron acceptor groups such as cyano, nitro, trifluoromethyl, COOR.sub.8, CONR.sub.9 R.sub.10 or CO-B;wherein R.sub.8 is hydrogen or lower alkyl;R.sub.9 and R.sub.10 are the same or different and selected from hydrogen, lower alkyl and cycloalkyl;B is selected from ##STR3## wherein m is 1, 2, 3 or 4. R.sub.11 is selected from hydrogen or lower alkyl, and the pharmacologically active salts thereof.The new compounds are useful for treating mental disorders.